INHIBITION OF PROTEASES AND ANTI-CANCER ACTIVITIES OF ETHANOLIC TUBER EXTRACT OF GLOBBA BULBIFERAAbstract
Studies on anticancer and protein inhibition process play a vital role in regulating the cellular process of life and diseases. The present studies have been conducted on ethanolic tuber extract from Globba bulbifera for protease inhibition and breast cancer inhibition. The extract has shown good inhibition for Trypsin, Chymotrypsin and protease K. The extract has also shown MCF-7 (Breast Cancer) inhibition, IC50 value at 235 μg/ml. The inhibition is less compared to the standard compound, tamoxifen (IC50: 37 μg/ml). Hence the present studies have shown good protease inhibition and anticancer (breast cancer) activities.
V. N. Rao and D. S. V. G. K. Kaladhar
Department of Biochemistry, GIS, GITAM University , Visakhapatnam, Andhra Pradesh, India.
19 November 2013
21 December 2013
26 December 2013
01 January 2014