IN-VITRO ANTIPLASMODIUM ACTIVITY OF DIFFERENT EXTRACTS BAUHINIA VARIEGATA
AbstractMalaria remains a major global health concern due to increasing resistance of Plasmodium falciparum to existing antimalarial drugs. The present study evaluates the in-vitro anti-plasmodial activity and cytotoxicity of methanolic and aqueous leaf extracts of Bauhinia variegata. Extracts were prepared using Soxhlet and maceration methods and subjected to phytochemical screening. Anti-plasmodial activity was assessed against chloroquine-sensitive (3D7) and resistant (Dd2) strains using a microfluorimetric DNA-based assay, while cytotoxicity was evaluated on PBMCs using the trypan blue exclusion method. The methanolic extract exhibited potent activity with low IC₅₀ values (1.32 and 1.54 µg/mL) and high selectivity indices, along with low cytotoxicity. The aqueous extract showed moderate activity. Hemolytic studies confirmed minimal toxicity to erythrocytes. These findings suggest that B. variegata, particularly its methanolic extract, holds promise as a potential source of novel antimalarial compounds.
Article Information
9
459-463
480 KB
8
English
IJP
Vikash Jha *, Raman Shivhare, Yogendra Singh and Sunil Singh
Shri Ramnath Singh Mahavidyalaya (Pharmacy), Gormi, Bhind, Madhya Pradesh, India.
mspharma8081@gmail.com
15 April 2026
06 May 2026
13 May 2026
10.13040/IJPSR.0975-8232.IJP.13(5).459-63
15 May 2026
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