HEPATOPROTECTIVE ACTIVITY OF MORUS ALBA (LINN). LEAVES EXTRACT AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATSAbstract
Aim: To investigate the hepatoprotective activity of Morus alba Linn. alcoholic leaves extracts against paracetamol-induced hepatitis in rats. Materials and Methods: The Morus alba leaves extracted with alcoholic (ALE), and water extract (AQE) against Paracetamol induced hepatotoxicity and using Standard drug is Liv-52. Preliminary phytochemical tests were done. Results: The ALE showed presence of alkaloids, flavonoids, carbohydrates, tannins, and steroids, did not produce any mortality. Paracetamol produced significant changes in biochemical parameters (increases in serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alanine phosphatase (ALP) and serum bilirubin.), histological (damage to hepatocytes) using Standard drug Liv-52. Pre-treatment with ALE extract significantly prevented the biochemical and histological changes induced by Paracetamol in the liver. Conclusion: The present study shows that the ALE extract possessed hepatoprotective activity.
M. G. Hogade * and S. S. Kuthar
Department of Pharmacognosy and Phytochemistry, Vilasrao Deshmukh Foundation,Group of Institution, VDF School of Pharmacy, New MIDC, Latur, Maharashtra, India.
19 February 2021
28 March 2021
30 March 2021
31 March 2021