HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT FROM THE STEM BARK OF SYNEDRELLA NODIFLORA ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN SWISS ALBINO RATSAbstract
The ethanol extracts of stem bark of Synedrella nodiflora belonging to the family of Asteraceae was studied for hepatoprotective activity against Swiss Albino Rats with liver damage induced by carbon tetrachloride (CCl4). It was found that the ethanol extract of Synedrella nodiflora at a dose of 250 mg/kg body weight exhibited significant protective effect by lowering the serum level of alanine aminotransferase (ALT) or serum Glutamate Pyruvate Transferase (SGPT), and 100 mg/kg body weight exhibited significant protective effect by lowering both the serum levels of alanine aminotransferase (ALT) or serum Glutamate Pyruvate Transferase (SGPT), aspartate aminotransferase (AST) or serum glutamate oxaloacetate transaminase (SGOT). The highest hepato-protective activity was observed for ethanol extract of Synedrella nodiflora at a dose of 250 mg/kg body weight, and the reduction of serum level of ALT, AST and serum bilirubin were 60.918 ± 0.7936, 81.479 ± 2.85039 and 0.5205 ± 0.0249 respectively. Since, result of biochemical studies of blood sample of carbon tetrachloride treated rats showed significant increase in the level of serum enzyme activities , reflecting the liver injury caused by CCl4 and blood sample from the animals treated with the ethanol extract of Synedrella nodiflora showed significant decrease in the level of serum marker, indicating the protection of hepatic cells, the extract of above plant could afford significant dose-dependent protection against CCl4 induced hepatocellular injury.
T. Kabir * and M. R. Hossain
Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka, Bangladesh.
17 March 2014
15 April 2014
30 April 2014
01 May 2014