FREE RADICAL SCAVENGING ACTIVITY OF RAUWOLFIA SERPENTINA RHIZOME AGAINST CCl4 INDUCED LIVER INJURYAbstract
Rauwolfia serpentina has a great reputation as a miracle medicinal plant, reported in various texts of the indigenous system of medicine. As, free radicals and diseases have great correlation; therefore, in the present study, free radical scavenging activity of methanolic extract (MET) of rhizomes of mature Rauwolfia serpentina was investigated by using CCl4 induced hepatotoxicity model in albino rats. The MET exhibited significant free radical scavenging activity by showing increased levels glutathione peroxidase (GPX), glutathione-S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and decreased the level of lipid peroxidation (LPO). The MET, at a dose level of 400 mg kg-1 showed significant free radical scavenging activity against CCl4 induced liver injury in rats. MET of R. serpentine had been shown prominent antioxidant activity and CCl4 intoxicated liver recovery towards normalcy.
A. K. Gupta *, R. Irchhaiya , H.R. Chitme and N. Misra
University Institute of Pharmacy, C.S.J.M. University, Kanpur, Uttar Pradesh, India.
28 December 2014
19 January 2015
24 February 2015
01 March 2015