FORMULATION AND EVALUATION OF ANTIBACTERIAL GEL USING LEAF EXTRACT OF PERGULARIA DAEMIA LINNAbstract
Pergularia is an annual herbaceous plant in the family of Pergularia daemia linn native to India and Shrilanka. Pergularia daemia linn has shown anti-bacterial property which makes it an essential herb in the treatment of various infections. This study was to check the effectiveness of Pergularia daemia lin against the microbial species Staphylococcus aurens, to observe the zone of inhibition and to develop a topical gel formulation of Pergularia daemia linn for the treatment of acne. The extraction was done by maceration method and continues with phytochemical screening and herbal gel formulation using hydroxypropyl methyl cellulose as a base with different concentration 2%v/v, 4%v/v, 6%v/v and 8%v/v. The gel was evaluated for the physical appearance, ph, homogeneity and antibacterial activity. Different concentration of Pergularia daemia linn methanolic extract exhibited relatively good antibacterial activity. It was concluded that the gel formulation having higher concentration (8%) is found to be good consistency compared to 2%, 4% and 6%v/v and can be used to treat the antibacterial activity.
Raman Chandak * and Santosh Rahate
Department of Pharmacognosy, School of Pharmacy, G. H. Raisoni University, Nagpur, Maharashtra, India.
12 August 2023
26 August 2023
30 August 2023
31 August 2023