EVALUATION OF IN VITRO ANTI CANCER ACTIVITY OF HYDROALCOHOLIC FLOWER EXTRACT OF BUTEA MONOSPERMA VAR. LUTEAAbstract
Butea monosperma var. lutea, a native of India, is commonly known as “Palash” and popularly known as “Flame of Forest.” Traditionally it has been found that flowers have antimicrobial, wound healing, antifungal, antidiarrhoeal, hypoglycemic, hepatoprotective, antioxidant, anthelmintic, anti-convulsive, antistress, antidiabetic, anti-inflammatory activity. In the present study, crude hydroalcoholic flower extract was examined for anticancer activity. To determine in-vitro anticancer activity, different concentrations of crude extract were tested on MCF-7 breast cancer cell line by 3-(4,5-dimethyl thiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The extract showed significant antiproliferative activity and a dose-dependent effect. Minimum inhibition 16.8% was shown by extract at concentration 62.5 µg/ml and maximum inhibition (46.89%) observed at 500 µg/ml. The flower extract showed activity in the potential range for further investigation of cancer cells.
M. A. Kamble *, D. M. Dhabarde , A. R. Ingole and A. P. Sant
Kamla Nehru College of Pharmacy, Butibori, Nagpur, Maharashtra, India.
02 February 2015
23 March 2015
29 March 2015
01 April 2015