EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SYZIGIUM ALTERNIFOLIUM (WIGHT) WALP.Abstract
Ethanol extract from the stem bark of Syzygium alternifolium exhibited significant activity against thioacetamide toxicity in rats. Glutamic oxaloacetic transaminase, alkaline phosphatase, total bilirubin, total cholesterol, lactate dehydrogenase, and total protein in serum indicated the hepatoprotective effect of the ethanol extract. Histopathological examination of liver sections confirmed that pre-treatment with ethanol extract prevented hepatic damage induced by thioacetamide. The results were compared with the standard hepatoprotective drug silymarin. The extract showed no signs of toxicity up to a dose level of 2000 mg/kg. It is suggested that the presence of flavonoids in ethanol extract may be responsible for hepatoprotective properties. Results indicate the hepatoprotective properties of ethanol extract of Syzygium alternifolium.
S. V. S. Kumar *, V. Rajeswari, D. K. Babu and Y. S. R. Reddy and D. Biswas
Creative Educational Society’s College of Pharmacy, Chinnatekur, Kurnool, Andhra Pradesh, India
16 August 2015
02 September 2015
18 September 2015
30 September 2015