EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF LEAVES EXTRACT OF CARISSA CARANDAS LINN.Abstract
Carissa carandas Linn. is an evergreen plant of the Apocynaceae family. It is native to India and also found in Bangladesh, Sri Lanka, Indonesia, Malaysia, Pakistan, and Myanmar. Almost every part of these plants has been investigated for various pharmacological activities. Among all parts, leaves are less investigated. The present study explores the hepatoprotective activity of 60 % ethanolic extract of leaves of Carissa carandas Linn. Extraction of fresh mature leaves by the process of maceration using Petroleum ether gave 0.84 gm crude extract and a yield of 1.68 %. Extraction by using 60 % Ethanol gave 6.9 gm and a yield of 13.8 %. This crude extract was investigated for the evaluation of a hepatoprotective activity. The carbon tetrachloride (CCl4) induced method was used to study hepatoprotective activity. The extract showed significant dose-dependent hepatoprotective activity when compared with negative control group as the release of enzymes and bilirubin decreased with increasing dose of extract.
Sumsunnahar Shifa, Taslima Begum, Faruquzzaman and Pritesh Ranjan Dash *
Department of Pharmacy, Primeasia University, Dhaka - 1213, Bangladesh.
08 April 2022
25 June 2022
28 June 2022
30 June 2022