EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF KANDANGKATHIRI KIRUTHAM IN ANIMAL MODELAbstract
Kandangkathiri Kirutham (ghee of Solanum xanthocarpum) is a Siddha herbal formulation mentioned in Siddha textbook for the treatment of Ullnaakku Azharchi (Tonsillitis). It contains leaf juice of Kandangkathiri (Solanum xanthocarpum), cow’s ghee, the paste of raw drugs namely Sittrarathai (Alpinia officinarum), Sittramutti (Sida cordifolia), Nerunjil ver (Tribulus terrestris), Chukku (Zingiber officinale), Milagu (Piper nigrum), Thippili (Piper longum) respectively. In the present study, the anti-inflammatory activity of Kandangkathiri Kirutham is evaluated by carrageenan-induced paw edema in rats using Diclofenac sodium as the standard drug. The animals were divided into 4 groups, of which, Group I (Negative control) is injected with carrageenan into the sub-plantar region of the hind paw of rats, Group II & Group III are injected with carrageenan + Kandangkathiri Kirutham (100 mg/kg) & (200 mg/kg) respectively. Group IV is injected with carrageenan + Standard Diclofenac sodium (50 mg/kg). The change in hind paw volume was measured using plethysmometer and expressed as mean paw volume of the rats. The formulation showed significant reduction of paw volume in rats. The results suggest that Kandangkathiri Kirutham has anti-inflammatory activity in rats.
S. Mahalakshmi *, S. Gandhimathi and V. Rani
Department of Kuzhanthai Maruthuvam, Govt. Siddha Medical College, Chennai, Tamil Nadu, India.
12 September 2015
19 November 2015
28 November 2015
30 November 2015