EVALUATION OF ANTI-DIARRHEAL AND DIURETIC ACTIVITY OF TABERNAEMONTANA DIVARICATA LINN. LEAVESAbstract
The aim of the present work was to investigate the anti-diarrheal and diuretic potentials of Tabernaemontana divaricata Linn. leaves of the family Apocynaceae. In almost all tropical developing countries of the world, diarrhoea is one of the most common and serious diseases, the principal cause of morbidity and mortality among children under five years. The methanolic extract of the leaves of T. divaricata L. was evaluated for anti-diarrheal properties in castor-oil induced diarrhoea. In the castor oil induced diarrhoea, MELTD significantly inhibited the number of defecations. The diuretic activity of the methanolic extract of leaves of T. divaricata (MELTD) was assessed based on Lipschitz value and diuretic index. The standard diuretic drug furosemide exhibited a significant increase in the urinary excretion of water and electrolytes (Na+ and K+), which is comparable with the extract. The diuretic index at the dose of 200 mg/kg (MELTD) was calculated as 1.55, significant as compare to the standard drug having a diuretic index of 1.70.
S. Kumari *, A. Mazumder and S. Bhattacharya
Noida Institute of Engineering and Technology, Institute of Pharmacy, Greater Noida, Uttar Pradesh, India.
06 March 2018
24 March 2018
30 March 2018
01 July 2018