EFFECT OF GYNANDROPSIS PENTAPHYLLA LEAVES ON MILK INDUCED EOSINOPHILIA AND LEUCOCYTOSIS IN MICE

Gynandropsis pentaphylla syn. Cleome pentaphylla, (Capparadiaceae) is commonly known as ‘Pandharitilvan and Safedhulhul.’ G. pentaphylla is an annual, erect, branched plant various parts of the plant are reported as rubefacient, counter-irritant, anthelmintic, in neuralgia, headache, and otalgia. Terpenes, β-carotene, sterols, fatty acids, flavonoids, glycosides, and alkaloids were reported from various part of the plant. The seeds are anthelmintic and rubefacient and used internally for the expulsion of round worms and externally as a counter irritant and in headache. The seeds and leaves of G. pentaphylla have immunosupressent, anthelmintic, antifungal and antimicrobial activity. The objective of present work is to evaluate different extracts of G. pentaphylla for preliminary phytochemical screening and milk induced eosinophilia and leucocytosis in mice. The different extract shows the presence of alkaloids, tannins, flavonoids, and saponins. All the extracts were found to be significantly effective against eosinophilia and leucocytosis in mice. The aqueous and methanolic extracts shows prominent inhibition when compare with standard drug dexamethasone.