DETERMINATION OF MEXILETINE IN PHARMACEUTICAL PREPARATIONS BY LINEAR SWEEP VOLTAMMETRYAbstract
A simple and rapid method for the determination of mexiletine in pharmaceutical preparations was developed and validated using linear sweep voltammetry (LSV). The proposed method was based on electrochemical oxidation of mexiletine at a platinum electrode in an acetonitrile solution containing 0.1M LiCIO4. The well-defined an oxidation peak was observed at +1.11 V. The calibration curve was linear for mexiletine at the concentration range of 5-70 µg/mL for LSV method. Intra- and inter-day precision values for mexiletine were less than 2.73, and accuracy (relative error) was better than 3.89%. The mean recovery of mexiletine was 100.1% for a pharmaceutical preparation. No interference was found excipient at the selected assay conditions. The method was found to be specific, precise and accurate. The method was applied for the quality control of commercial mexiletine capsule form to quantify the drug and to check the formulation content uniformity.