COMPARATIVE NEPHRO-HEPATOPROTECTIVE EFFECTS OF HERBAL TEAS FROM HIBISCUS SABDARIFFA, MORINGA OLEIFERA, ZINGIBER OFFICINALE, AND AZADIRACHTA INDICA IN ALLOXAN-INDUCED DIABETIC MALE WISTAR RATS: A PRECLINICAL STUDY

Diabetes, a silent killer, ravages the kidney and liver, leaving a trail of destruction in its wake. Studies have suggested a link connecting dysfunctional liver and renal activity alongside glucotoxic retinopathy in patients of type 2 diabetes mellitus. Against this background, our preclinical study unveils the remarkable nephro-hepatoprotective effects of herbal teas from Hibiscus sabdariffa, Moringa oleifera, Zingiber officinale and Azadirachta indicain diabetic male Wistar rats induced with alloxan. Diabetes of artificial source was administered through a one-time interperitoneal administeration of about seven categories having 6 rats in the individual group. control (glycemic), diabetic groupthat is made up of alloxan treatment + Zobo (100+400 mg/kg)., alloxan + moringa (100 +200 mg/kg), alloxan + ginger (100+500 mg/kg), alloxan + Dogoyaro (100+250 mg/kg), and lastly, the alloxan +glibenclamide (100+5mg/kg) were orally given for 28 days. Reduction of tissue weight was observed upon administration of alloxan which was ameliorated upon treatment with the selected herbal teas. Also, elevated levels of liver and kidney biomakers induced by alloxan were reversed upon administration of the Herbal teas. Furthermore, the Herbal teas decreased fasting blood glucose, which was initially significantly increased by alloxan (p<0.05). Consequently, given to their antihyperglycemic and nephro-hepatoprotective prowess, these selected herbal teas offer a beacon of hope for the millions afflicted not just with diabetes but also diabetes-related kidney and liver diseases.