CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF GENUS RUELLIAAbstract
The genus Ruellia L. is sometimes called Dipteracanthus, it comprises about 150 species native to tropical and temperate North and South America. In this review, the literature data on phytochemical and biological investigations of the genus Ruellia are compiled. The well-recognized groups of secondary metabolites were flavonoids, lignans, coumarins, alkaloids, triterpenes, sterols, phenolic glycosides, phenylethanoids, megastigmane glycosides, benzoxazinoid glucosides, and others. The extract of this genus as well as pure compounds isolated from it have been demonstrated to possess multiple pharmacological activities such as wound healing, cardio-vascular, anti-hyperglycemic, antioxidant, antimicrobial, antibacterial, anticancer, antinociceptive, anti-inflammatory, cytotoxic and gastro-protective activities, purgative and angiotensin-converting enzyme-inhibitory effects, estrogenic and cholinergic properties and anti-fertility action.
M. N. Samy *, S. Sugimoto, K. Matsunami, H. Otsuka and M. S. Kamel
Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi, Minami-ku, Hiroshima, Japan.
30 April 2015
24 June 2015
28 June 2015
30 June 2015