ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF WHOLE PLANT OF TECOMA CAPENSIS THUMB.Abstract
Objective: The study was designed to explore the anti-oxidant, anti-microbial and anti-inflammatory activity of Tecoma capensis Thumb. (T. capensis) whole plant extract. Material and Method: Antioxidant and free radical scavenging activity of extract of ethanolic extract of Tecoma capensis was investigated against 2, 2 Diphenyl-1-picrylhydrazyl (DPPH) assay, superoxide radical and hydroxyl radical scavenging activity compared with that of standard (ascorbic acid) and antimicrobial activity was evaluated against clinically important bacterial strain those were Bacillus subtilis, Staphylococcus aureus (gram +ve), Escherichia coli, Proteus vulgaris (gram -ve) and two fungal strain Aspergillus niger, Candida albicans using cup plate method. Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema method by the oral administration of EETC (100, 250 mg/kg). The data were statistically analyzed by ANOVA. Results: The IC50 values were determined by radical scavenging activity of EETC by DPPH (21 ± 0.06), superoxide radical (37.2 ± 0.04) and hydroxyl radical scavenging activity (12 ± 1.64). The average zone of inhibition for EETC against S. aureus (15 ± 0.816) and E. coli (15.2 ± 0.5). Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema method by the oral administration of EETC (100, 250 mg/kg) exhibited significant and dose-dependent anti-inflammatory activity. Conclusion: it is concluded that the EETC showed significant and dose-dependent activities. Therefore, this plant can be used for new pharmacological research accomplishment.
K. Padmaja*, G. Seru, J. Panda and M. Sulakshna
Raghu College of Pharmacy, Dakamarri, Bheemunipatnam (M), Visakhapatnam, Andhra Pradesh, India.
10 October 2017
14 November 2017
18 November 2017
01 February 2018