ANTIDIARRHEAL, ANTIDIABETIC, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACTS OF LEAVES OF CLERODENDRUM VISCOSUM (VENT.)Abstract
The present study was aimed to investigate the possible antidiarrheal, antidiabetic, antioxidant and antimicrobial activity of methanolic extracts of leaves of Clerodendrum viscosum (Vent.) Different screening models are employed for an investigation like Castor oil induced diarrheal model for antidiarrheal activity screening, alloxan-induced diabetic model for antidiabetic activity screening, antioxidant activity by DPPH scavenging method and disc diffusion method for the antimicrobial activity screening. Clerodendrum viscosum (Vent.) shows good anti-diabetic, antidiarrheal and antioxidant activity but having no antimicrobial activity in relationship with the standard drug. Clerodendrum viscosum (Vent.) methanolic extract dose of 500mg/kg significantly reduces the blood glucose level at a 1st hour to 3rd hour 130 to 36 mg/dL in in–vivo mice model. During antidiarrheal screening, Clerodendrum viscosum (Vent.) extract dose reduces the number of stool from 3 to 1in 1st hour to 3rd of treatment. DPPH scavenging activity on Clerodendrum viscosum (Vent.) was significant with the standard. IC50% 8.93 µg/mL and 7.8 µg/mL for sample Clerodendrum viscosum (Vent.) and standard ascorbic acid respectively.
M. S. Hossain, J. Islam, R. Sarkar and S. M. M. Hossen *
Department of Pharmacy, University of Chittagong, Bangladesh.
01 May 2014
08 June 2014
30 June 2014
01 July 2014