ANTIDIABETIC ACTIVITY ETHANOLIC LEAVES EXTRACT OF BAUHINIA GALPINII LINN. ALLOXAN INDUCED DIABETIC IN RATS

Aim of the study: This study aimed to investigate the antidiabetic activity of ethanolic leaves extracts of Bauhinia galpinii Linn. alloxan, induced diabetic in rats. Materials & methods: The adult male albino rats of weight 180-240 gm were selected for the study. The Dose of 100 mg/kg, 250 mg/kg and 500 mg/kg of ethanol extract was selected for the test. All the doses were given orally after making an emulsion in the vehicle, i.e., 1% acacia gum and the standard drug, i.e., glimepiride was given orally (10 mg/kg) in the vehicle. Diabetes mellitus was induced by administering an intraperitoneal injection of alloxan monohydrate 120 mg/kg to the overnight fasted rats. A blood sample was collected from tail nipping, and an automatic electronic glucometer determined glucose level. Ethanolic extract of Bauhinia galpinii Linn. leaves were subjected to anti-diabetic activity in rats where alloxan monohydrate (120 mg/kg b.w., i.p.) used as the diabetogenic agent. A marked rise in fasting blood glucose level observed in diabetic control compared to normal control rats. Results: In the present Ethanolic extract of Bauhinia Galpinii Linn (at 250 and 500 mg/kg) exhibited a dose-dependent significant anti-hyperglycemic activity on 4^th, 7^th, and 10^th-day post-treatment. The extract dose of 100 mg/kg also caused a reduction in blood glucose level, but the results were found statistically insignificant. The antihyperglycemic effect of ethanol extract was found less effective than the reference standard. Glibenclamide produced a significant reduction in blood glucose compared to diabetic control. When the glucose tolerance test did the activity of the extract in glucose-loaded rats, ethanolic extract showed a significant effect on the blood glucose level, but an extract of 100mg/kg did not show the significant result. Ethanolic extract 250mg/kg and 500mg/kg showed a significant decrease in blood glucose level. Conclusions: The ethanolic extract of Bauhinia galpinii Linn. has a protective effect against alloxan, induced diabetic in rats.