AN OVERVIEW OF ANTI-CANCEROUS BEHAVIOR OF VITAMIN EAbstract
Imbalance of reactive oxygen species and their body neutralizing mechanisms defines oxidative stress. ROS play a vital role in cancer progression by taking part in DNA damage and induction of inflammatory processes. Studies reveal that natural anti-oxidant levels are reduced to a much lower extent in the serum of cancer patients in contrast to the healthy ones. Vitamin E subgroups like tocopherols and tocotrienols, being anti-oxidants, show anti-cancer abilities in human and animal cancer models. Cancer patients taking vitamin E diet are observed to have lowered reactive species; however, specific tocopherols in exception act as antagonists against chemotherapeutic drugs. This article reviews the role of pro-oxidants and anti-oxidants in cancer therapy, either alone or in combination with medications. It also highlights the drawbacks of taking vitamin supplements on cancer risks, incidences, and mortality rates.
I. Ashraf, S. Farooq, F. Ali, S. S. Anwar and N. Wajid*
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
12 June 2015
29 June 2015
28 July 2015
31 July 2015