AN OVERVIEW OF ANTI-CANCEROUS BEHAVIOR OF VITAMIN E
AbstractImbalance of reactive oxygen species and their body neutralizing mechanisms defines oxidative stress. ROS play a vital role in cancer progression by taking part in DNA damage and induction of inflammatory processes. Studies reveal that natural anti-oxidant levels are reduced to a much lower extent in the serum of cancer patients in contrast to the healthy ones. Vitamin E subgroups like tocopherols and tocotrienols, being anti-oxidants, show anti-cancer abilities in human and animal cancer models. Cancer patients taking vitamin E diet are observed to have lowered reactive species; however, specific tocopherols in exception act as antagonists against chemotherapeutic drugs. This article reviews the role of pro-oxidants and anti-oxidants in cancer therapy, either alone or in combination with medications. It also highlights the drawbacks of taking vitamin supplements on cancer risks, incidences, and mortality rates.
Article Information
2
320-325
603
1526
English
IJP
I. Ashraf, S. Farooq, F. Ali, S. S. Anwar and N. Wajid*
Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
Nadia.wajid@imbb.uol.edu.pk
12 June 2015
29 June 2015
28 July 2015
10.13040/IJPSR.0975-8232.IJP.2(7).320-325
31 July 2015
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