AMELIORATIVE EFFECT OF EMBLICA OFFICINALIS (AMLA) ON ALTERED BIOCHEMICAL MARKERS AND OXIDATIVE STRESS INDICES AFTER SUB-ACUTE ENROFLOXACIN TREATMENT IN ALBINO RATSAbstract
Background: The current study was conducted at the department of veterinary pharmacology and toxicology to assess the impact of Emblica officinalis on oxidative stress produced by sub-acute enrofloxacin exposure in albino rats. Methodology: Albino rats weighing 200-300 grams were given enrofloxacin and Emblica officinalis orally through gavage needle. Blood samples were taken via capillary tube on the 28th day of the experiment and analyzed using laboratory procedures. Result: Sub-acute treatment of enrofloxacin at doses of 5 mg/kg b.wt. and 10 mg/kg b.wt. generated oxidative stress in rats, as evidenced by substantial changes in oxidative parameters, and affected liver and kidney functions, as seen by changes in biochemical markers of liver and kidney function. Emblica officinalis aqueous extract (200 mg/kg b. wt.) effectively reduces oxidative stress and changes in hepatic and renal function caused by enrofloxacin. Conclusion: Emblica officinalis (Amla) has antioxidant properties and can reduce oxidative stress caused by enrofloxacin in albino rats following sub-acute treatment.
Prateek Mishra *, Vidhi Gautam, R. K. Sharma, Sachin Jain, Anushri Tiwari and Vijay Gond
Department of Veterinary Pharmacology & Toxicology, College of Veterinary Science & A. H. N. D. V. S. U. Jabalpur, Madhya Pradesh, India.
19 May 2022
19 July 2022
28 July 2022
31 August 2022