Posted by admin on Mar 15, 2018 in |
Introduction: Lichens are known for their ability to grow in a very harsh environment, on the other hand, it is proved that the more environmental stressors, the more phytochemicals are produced in plants and fungi. So, it is assumed that lichens contain a large amount of phytochemicals, which can be a great source of medicinally active compounds. Lichen extracts are served as therapeutic agents in many disorders, and great efforts are made to analyze and quantify their phytochemical contents. Objective: Qualitative screening of 32 lichen extracts, quantification of phytochemicals and total antioxidant capacity in some rich content extracts, and finally correlation of quantified phytochemical classes with their antioxidant activity. Methodology: Qualitative and quantitative screening was performed using standard methods and construction of standard compounds’ calibration line. Pearson’s bivariate correlation test was carried out for determination of correlation coefficient and coefficient determination. Results: Evaluated extracts were rich in flavonoids, phenols, and carotenoids, also phenols, flavonoids and antioxidant contents were internally correlated. Conclusion: According to the significant correlation between phenols, flavonoids...
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Posted by admin on Mar 15, 2018 in |
This study was aimed to maximize the benefits of the use of by-products (oil cake) of olive fruits and black seeds after extraction of their fixed oils, rather than their use as animals feed or landfilling or composting. The cake of both seeds was assessed by HPLC for their main bioactive marker compounds (thymoquinone for black seed and oleuropein for olive fruit), to choose the best method for extraction, determination of phenolic contents and in vitro antioxidant activity (DPPH and reducing powers, FRAP assays). Both by-products were also assessed for their cytotoxicity against four human breast cell lines, three of them are cancerous (MCF7, MDA-MB-213, Vcr-R), and a non-cancerous one (epithelial type) but immortalized by telomerase (hTERT-HME), in addition to a human hepatoma cell line (HepG2). Also, both wastes were subjected for in-vitro CDC25s phosphatase inhibition assay on three isoforms (A-C) and for in-vivo immunomodulatory effects. In conclusion, the results of this study showed the interest of cumulating different biological approaches exploring various physiological mechanisms and showed the utility...
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Posted by admin on Mar 15, 2018 in |
Gymnema sylvestre R. Br is a valuable herb extensively used in the ayurvedic and indigenous medicinal system, belonging to the family Asclepiadaceae. It has the property of abolishing the taste of sugar and hence given name gurmar (sugar destroying). This plant has also found application in pharmaceuticals; the whole plant is rich in secondary metabolites, which impart medicinal uses to the plant. The view of phytochemistry gives scope for enhancement of the quality and quantity of the bioactive secondary metabolites occurring in the plant. The present review is an attempt to highlight the various phytochemical reports on Gymnema...
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Posted by admin on Mar 15, 2018 in |
Stroke is the sudden blockage or rupture of cerebral arteries that can lead to cerebral damage or clinical neurologic deficit. Generally, stroke is as ischemic and hemorrhagic. Ischemia caused by factors such as thrombosis, embolism, and systemic hypoperfusion. Stroke is one of the most important factors of mortality and disability worldwide. After a stroke, an increase of free radicals has the most important role in the breakdown of blood-brain and increase of cerebral edema. This study aimed to review the effect of compounds isolated from plants to reduce cerebral ischemia. Our review showed that natural compounds could exert a protective effect by reduction of oxidative stress and events related to it. We also suggest that consider special attention to natural product for the treatment of cerebral...
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Posted by admin on Feb 5, 2018 in |
The objective of this research is to evaluate the preliminary phytochemical analysis and antibacterial activity from the medicinal plant of Hugonia mystax of Dindigul district, Tamil Nadu. The leaves of plant Hugonia mystax was subjected to Soxhlet extraction process by using solvent ethanol. Preliminary phytochemical analysis of ethanol extract of Hugonia mystax leaves showed the presence of carbohydrate, flavonoids, phenolic groups, saponins, steroids, tannins, and terpenoids. In-vitro antibacterial activity was performed by the plate hole diffusion method in MH agar medium. The bacteria used for the antibacterial study were Bacillus lichenformis (NCIM 2468), Brevibacterium luteum (ATCC 15830), Escherichia coli (ATCC 11775), Flavobacterium devorans (NCIM 2581), Klebsiella pneumonia (ATCC 11229), Micrococcus flavus (NCIM 2984), Micrococcus luteus (NCIM 1207). Ethanol extract of Hugonia mystax exhibited the best result of the maximum zone of inhibition observed against gram-positive as well as gram-negative bacteria. The anti-bacterial activity revealed the medicinal potential of Hugonia mystax to develop a drug against human...
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