Posted by admin on Apr 30, 2026 in |
Jatropha curcas L., a member of the Euphorbiaceae family, is a multipurpose medicinal plant widely distributed in tropical and subtropical regions. It possesses diverse phytochemicals such as flavonoids, alkaloids, diterpenoids, and phenolics, which contribute to its broad pharmacological profile. Traditional uses and experimental studies highlight its therapeutic potential, including anti-inflammatory, antimicrobial, antiviral, anticancer, antidiabetic, anti-arthritic, wound healing, and hepatoprotective activities. Various plant parts such as leaves, bark, seeds, latex, and roots have demonstrated significant biological effects in both in-vitro and in-vivo models. Additionally, the plant exhibits enzymatic activities and industrial applications, particularly in biofuel production and biocatalysis. Despite its medicinal benefits, toxicity at higher doses necessitates careful evaluation. Overall, J. curcas represents a promising natural resource for drug development and sustainable applications, warranting further pharmacological and clinical...
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Posted by admin on Apr 30, 2026 in |
Respiratory diseases remain one of the leading global health burdens, ranging from acute infections such as influenza and pneumonia to chronic conditions like asthma and chronic obstructive pulmonary disease. Conventional pharmacological agents, including bronchodilators, corticosteroids, antibiotics, and biologics, are widely recognized for their clinical efficacy and regulatory approval, yet their long-term use is often associated with adverse effects, drug resistance, and financial burden. In contrast, herbal medicines have been used for centuries in various cultural and traditional systems of medicine, offering potential anti-inflammatory, mucolytic, antiviral, antioxidant, and immunomodulatory benefits. Recent interest has increasingly focused on systematically comparing the effectiveness and safety of herbal therapies with conventional drugs, especially as patients actively seek holistic and integrative approaches to respiratory care. This review critically examines the available evidence on herbal interventions such as Echinacea, Pelargonium, licorice root, ginger, turmeric, and ivy leaf and contrasts them with standard pharmacological options including bronchodilators, corticosteroids, and mucolytic agents. Safety profiles, possible herb drug interactions, pharmacoeconomic aspects, and limitations of current studies are also evaluated....
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Posted by admin on Apr 30, 2026 in |
Herbal capsule formulations have gained significant attention due to their therapeutic potential, improved patient compliance, and growing global demand. However, their quality, safety, and efficacy are challenged by variability in raw materials, lack of uniform standards, and complex multi-component nature. This review highlights the comprehensive standardization of herbal capsule formulations, including raw material evaluation, physicochemical and phytochemical analysis, chromatographic fingerprinting, and capsule quality control parameters such as weight variation, disintegration, dissolution, and content uniformity. It also discusses microbiological safety, toxicological screening, and advanced techniques like DNA fingerprinting, marker-based standardization, and chemometric analysis. Regulatory frameworks from WHO, AYUSH, US FDA, and EMA are also summarized. Despite advancements, challenges such as lack of universal markers and variability in herbal sources persist. Integration of modern analytical tools with traditional knowledge is essential to ensure consistent, safe, and effective herbal capsule products for global...
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Posted by admin on Apr 30, 2026 in |
Ashwagandha serves as a crucial element within the Ayurvedic medicinal system and is incorporated into various Ayurvedic preparations aimed at addressing a range of health issues. Withania somnifera, commonly known as Ashwagandha, belongs to the Solanaceae family. It originates from the arid regions of India, Pakistan, and Sri Lanka. The roots, stems, and leaves of the Ashwagandha plant possess medicinal qualities, containing a diverse array of phytochemicals and nourishing compounds. Examination in laboratories has unveiled more than 35 chemical constituents located in the roots of Withania somnifera. These include withanolides, alkaloids, saponins, steroidal lactones, amino acids, phytosterols, fatty acids, and polyphenols. The presence of these phytochemicals and nutrients in Ashwagandha confers diverse pharmacological activities. In this article, a detailed literature review of the drug has been done in terms of its vernacular names, taxonomical hierarchy, distribution, agroclimatic condition, macroscopy, microscopy, phytochemical composition, nutrient profile, qualitative analysis including HPTLC, pharmacological activities, ayurvedic properties, marketed formulations and patents filed on...
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Posted by admin on Apr 30, 2026 in |
The present study involves the development and validation of simple, accurate, and precise analytical methods for the simultaneous estimation of Alprazolam and Sertraline Hydrochloride in combined pharmaceutical dosage forms. Two methods were developed: UV spectrophotometry and reverse-phase high-performance liquid chromatography (RP-HPLC). The UV spectrophotometric method utilized the simultaneous equation method based on absorbance measurements at 260 nm and 273 nm, the respective λmax values of Alprazolam and Sertraline HCl. Both drugs obeyed Beer’s Law in the concentration range of 5–50 μg/mL, with high correlation coefficients, indicating good linearity. The method showed satisfactory precision and accuracy, making it suitable for routine analysis. The RP-HPLC method was performed using a C18 column and a mobile phase composed of methanol, acetonitrile, and phosphate buffer (pH 4.5) in the ratio 50:15:35 v/v, at a flow rate of 1 mL/min. Detection was carried out at 239 nm, and the retention times were found to be approximately 3.0 minutes for Alprazolam and 6.4 minutes for Sertraline HCl. The method was validated according to ICH guidelines, and parameters such as specificity,...
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