Posted by admin on Sep 30, 2021 in |
Indole-3-carbinol, a phytoactive constituent obtained from cruciferous vegetables like Brussels, sprouts, cabbage and cauliflower. It has chemopreventive properties supported by numerous studies carried out to prevent breast, lung, prostate, leukemia and ovarian cancer. Indole-3-carbinol possesses therapeutic benefits like antimicrobial, neuroprotective and antitumor properties. However, it has got poor oral bioavailability due to limitations like metabolic instability in acidic media, thermal instability, etc. The review focuses on the chemistry, anticancer mechanism, limitations, bioavailability, pharmacokinetics, and toxicities studies related to I3C. It also focuses on analytical methods and current approaches for developing an improved delivery system for Indole 3 carbinol by overcoming bioavailability and toxicity limitations. I3C has reported showing limited efficacy in clinical trials due to its poor oral bioavailability. Hence administration of I3C from alternative routes is explored by formulating it as nanoparticles, nanocapsules, suspensions, microemulsions,...
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Posted by admin on Aug 31, 2020 in |
The purpose of the present research work was to formulate and evaluate vanishing herbal cream. Herbal creams offer several advantages over other creams. The majority of existing creams which has prepared from drugs of synthetic origin and give extras fairness to face, but it has several side effects such as itching or several allergic reactions. Herbal creams do not have any of these side effects; without side effects, it gives the fairness look to the skin. The method carried out to prepare herbal cream was very simple. Firstly, the oil phase was prepared, the mixture of stearic acid (17%), potassium hydroxide (0.5%), sodium carbonate (0.5%) were melted at 70 ºC. Secondly, the aqueous phase was prepared, a mixture of alcoholic extract of crude drugs, including C. officinalis and A. indica, Turmeric, Nutmeg, Cinnamon, are commercially available as extracts and in the different formulation to be used either for cosmetic purposes or for medical use. Glycerin (6%), perfume (0.5%), water (71%) heated at 70 ºC. Then aqueous phase was added...
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Posted by admin on Aug 31, 2020 in |
A field study was conducted at the Vegetable Research Farm, Banaras Hindu University, Varanasi, during rabi season 2016-2017 for the evaluation of newer insecticides (Imidacloprid 600 FS and Thiamethoxam 30 % FS) on plant growth characters of a garden pea. The two insecticides were applied as a seed treatment in different doses. The result of bio-efficiency revealed that the seed treatment with T₃ gaucho (Imidacloprid 600 FS) @ 2 ml/kg was found effective in promoting plant growth and increased germination % (93.84%) and maximum plant stand per meter square(m²) (30.40%). Less number of days to 50% flowering (43.33 days) and maximum plant height at last harvesting stage (91.07 cm) were also recorded in seed treatment with T₃ gaucho (Imidacloprid 600 FS), while there was no significant difference in plant height at 30 DAS and 45 DAS. However, all the seed treatment was found superior over untreated...
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Posted by admin on Aug 31, 2020 in |
The present study, carried out on Cymbopogon citratus was interested in volatile and no-volatile extracts of the plant. It focused on the effect of two types of extracts on eleven strains of bacteria. Chemical analysis of the volatile extract obtained with a yield of 2.28% revealed the presence of 72.91% of citral and other minority compounds. The extraction yield of the ethanolic extract (no-volatile) is 10.8%. Chemical groups such as reducing compounds, alkaloids, flavonoids, phenolic compounds, leuco-anthocyanins, saponosides, coumarins, and finally, terpenoids have been identified in this extract. The Minimum Inhibitory Concentration (MIC) and Bactericidal (CMB) were determined by macro dilution method. The volatile extract showed the best inhibitory activities on more than 90% of the strains of bacteria studied. The lowest minimum inhibitory concentrations were obtained against Micrococcus luteus (0.3125 mg/ml), Staphylococcus epidermidis T22695 (0.625 mg/ml) and Proteus vulgaris A25015 (0.625 mg/ml). This extract also had the best inhibition diameters against most bacteria. The bactericidal activity of this extract was only obtained against Enterococcus faecalis (1.25 mg/ml). The...
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Posted by admin on Aug 31, 2020 in |
Marine natural products are currently acknowledged as the most significant source of bioactive substances and medications with phenomenal biodiversity. Marine plants and creatures, for example, algae, bacteria, sponges, fungi, seaweeds, corals, diatoms, ascidians, are significant sources of the ocean and contain over 90% of the complete ocean biomass. Because of its exceptional biodiversity, the sea world is a rich common asset for some biologically active compounds. About half of the world’s biodiversity is a marine organism; thus, the seas and oceans are viewed as the biggest repositories with an immense assortment of new substances and natural molecules of benefit. During the previous four decades, various novel compounds have been confined from a marine organism, and a large number of these substances have been appeared to have intriguing biologic potential.This review is an ongoing update of data about efficient marine eugicons (proteins, peptides, amino acids, fatty acids, sterols, polysaccharides, oligosaccharides, phenolic compounds, photosynthetic pigments, vitamins, and minerals) and spotlight on their potential health benefits. Accordingly, the work assessed so far...
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