Posted by admin on Sep 29, 2016 in |
This study was carried out to evaluate the thrombolytic and membrane stabilizing activities of Launaea sarmentosa plants. The crude methanolic extract of L. sarmentosa (whole plants) was investigated for in-vitro thrombolytic and membrane stabilizing activities at five different concentrations of 2, 4, 6, 8 and 10 mg/ml respectively. In the case of thrombolytic study, it was dose-dependently increased (p<0.01), where streptokinase (30,000 I.U.) was used as standard, and distilled water was treated as a negative control. In the in vitro clot lysis assay method, 10 mg/ml concentration most significantly showed 22.57% lysis of clot (p<0.001). Similarly, crude methanolic extract of L. sarmentosa dose-dependently increased the membrane stabilizing activity in comparison to the standard drug, acetylsalicylic acid (0.10 mg/ml; p<0.01). 10 mg/ml of the extract exhibited 12.11% and 20.55% inhibition of hemolysis by both hypotonic solution and heat-induced hemolysis,...
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Posted by admin on Sep 29, 2016 in |
The purpose of the study was to determine the leaves of Andrographis serpyllifolia for anti-diabetic and antihyperlipidemic effects in streptozotocin-induced diabetic rats. The aqueous, alcoholic and hydroalcoholic extracts of Andrographis serpyllifolia were tested for toxicity up to 4000 mg kg-1 as per OECD-425 guidelines. Anti-diabetic activity was assessed by oral glucose tolerance test and streptozotocin-induced model. In oral glucose tolerance test alcoholic and hydroalcoholic extracts exhibited greater activity compared to aqueous extract. Hence the alcoholic and hydroalcoholic extracts were further screened by the streptozotocin-induced model at 75, 150 and 300mg kg-1 for 15 days. The alcoholic and hydroalcoholic extracts effectively lowered serum glucose, triglycerides, cholesterol, low-density lipoproteins, very low-density lipoproteins, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine, and elevated high-density lipoprotein levels, body weight and liver glycogen levels. The alcoholic and hydroalcoholic extracts elicited dose-dependent effect, and the effect produced at the lower dose was not considerable. Hydroalcoholic extract (300 mg kg-1) elicited greater anti-diabetic and antihyperlipidemic activity compared to alcoholic extract (300 mg...
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Posted by admin on Sep 29, 2016 in |
Since, the middle ages, essential oils have been widely used for bactericidal, fungicidal, insecticidal, virucidal, cosmetic and medicinal applications, especially nowadays in agriculture, food, sanitary and pharmaceutical industries. Distillation is the common mode of extraction used for aromatic plants, which results in a variety of volatile molecules such as terpenes, terpenoids, aliphatic components, and phenol derived aromatic components. Extensive research has been done in the last decade to screen and evaluate the pharmaceutical potential of the phytochemical constituent, terpinen-4-ol. It is found in various plants species and has gained attention because of its antiviral, antibacterial, anti-inflammatory and antifungal properties. This monoterpene is a bioactive component of tea tree oil (TTO) present in a plant belonging to the genus Melaleuca. In the present review, an overview of the current status and knowledge on the physicochemical properties, analytical techniques, formulations, pharmacological applications, irritation and toxicity potential of terpinen-4-ol have been...
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Posted by admin on Sep 2, 2015 in |
The present study was investigated to determine the possible phytochemical components from the solvents such as hexane, ethyl acetate and ethanolic extract of Aerva lanata. Among the phytochemical screening of these extracts, ethanolic extract showed that the whole plant was rich in carbohydrate, tannin, flavonoids, quinones, cardiac glycosides, phenols, and coumarins. Further, the study was extended by analyzing the antioxidant potential using DPPH method. Among all the extracts ethanolic extract showed better antioxidant activity at the concentration of 75 µg/ml when compared to other...
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Posted by admin on Sep 2, 2015 in |
The aim of the present study is the phytochemical screening of gum of Curcuma amada (Mango ginger). Natural gums are economic, easily available and found useful as a tablet binder. The phytochemical properties of a gum obtained from the rhizomes of Curcuma amada were characterized by various test including a test for steroids, tannins, flavonoids, amino acids, carbohydrates, and glycosides. All of the test except for carbohydrates were negative confirms the presence of...
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