Posted by admin on Jun 30, 2025 in |
Hyperlipidemia is a significant contributor to the global burden of cardiovascular diseases, such as coronary heart disease and stroke. Characterized by elevated plasma lipids, including cholesterol, triglycerides, and lipoproteins, hyperlipidemia is a prevalent health issue with increasing incidence in both developed and developing countries. According to the World Health Organization (WHO), raised cholesterol levels are linked to 4.5% of global deaths and account for 29.7 million disability-adjusted life years (DALYs) annually. The Fredrickson classification system, endorsed by WHO, categorizes hyperlipidemia into six types based on lipoprotein abnormalities, providing a foundation for understanding its diverse etiologies and clinical implications. Experimental induction of hyperlipidemia is pivotal for studying its pathophysiology and testing potential therapeutic interventions. Various screening methods have been developed, including the use of pharmacological agents, dietary modifications, and genetic models. This review discusses the epidemiology, classification, and methodologies used to induce hyperlipidemia in experimental settings, highlighting their relevance in advancing our understanding and management of this critical public health...
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Posted by admin on Jun 30, 2025 in |
This work aims to contribute to the phyto-therapeutic treatment of oral diseases that do not have a recognized management program, such as malaria, HIV-AIDS and tuberculosis. The aim is to qualitatively and quantitatively determine the chemical composition of Anacardium occidentale and Cocos nucifera, as well as the toxicity and sensitivity to their extracts of the microbial strains responsible for oral infections. Medicinal plant sellers in 03 markets of Porto-Novo use plant species to treat oral infections. C. nucifera (A) and A. occidentale (B) were the most frequently cited, used in decoction form. Qualitative phytochemical analysis using the standard method showed that C. nucifera roots contain tannins, steroids, mucilages, leuco-anthocyanins and alkaloids, while A. occidentale roots contain tannins, flavonoids, anthocyanins, leuco- anthocyanins, steroids, reducing compounds, coumarins and mucilages. The contents of total phenols (18.79±0.46 mgEAG/g(A)) and (20.05±1.01 mgEAG/g (B)), flavonoids (39.04±18.8 mgEQ/g) for extract B, condensed tannins (8.36±0.22 mgEC/g (A)) and (5.77±0.27mgEC/g(B)), justify the biological potential of these plants. Evaluation of the free radical scavenging activity of the decocts of...
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Posted by admin on Jun 30, 2025 in |
Objective: Knowledge about medicinal plants can contribute to modern therapeutics. Impatience walleriana [Family: Balsaminaceae] an ornamental, nutritive herb has relevance in African and Asian traditional medicines. Traditionally I. walleriana is used for anti-inflammatory, anti-dermatitis effects and is known to relieve skin irritation. It is applied on skin to treat bacterial and fungal infection. Acne is a common skin disorder mainly seen in adolescents. Treatment for acne revolves around anti-bacterial, anti-inflammatory and antioxidant effects of drugs. Anti-bacterial and antioxidant activities of I. walleriana have been reported previously reported. In the present study anti-acne potential of I. walleriana extract is evaluated against Propionibacterium acne and an attempt has been made to co-relate findings with traditional claims. Methods: Hydroalcoholic extract of aerial parts of I. walleriana is evaluated for effectiveness against P. acne by measuring zone of inhibition using well diffusion method and by finding MIC. Tetracycline is used as standard. Results: Results of Zone of Inhibition are promising with an average of 11mm, 08mm and 4mm in the duplicate readings obtained....
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Posted by admin on Jun 30, 2025 in |
Catharanthus roseus, population known as Vinca rosea, is a significant medicinal plant from the Apocynaceae family, used to treat various life-threatening diseases. It is known by names such as bright eyes, cape periwinkle, pink periwinkle, and Madagascar periwinkle. The plant contains chemical compounds like carbohydrates, flavonoids, saponins, and alkaloids, including vinblastine, vincristine, vindoline, monoterpenes, sesquiterpenes, indole, and indoline glycosides. Catharanthus roseus is native to the Indian Ocean Island of Madagascar and was once considered an endangered species in the wild. However, it is now found in many tropical and subtropical regions worldwide, including the southern United States. The plant demonstrates various pharmacological activities, such as anticancer, antidiabetic, antimicrobial, antioxidant, memory enhancement, wound healing, hypotensive, antidiarrheal, antiulcer, and hypolipidemic effects. In this review article express taxonomy, synonym, vernacular names, distribution, ethnomedical uses, phytochemicals and pharmacological activities of Catharanthus...
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Posted by admin on Jun 30, 2025 in |
Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately, these drugs cause increased risk of blood clot resulting in heart at tacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. Due to these side-effects, there is need for the search of newer drugs with less or no side-effects. There are hundreds of phytoconstituents reported to have many pharmacological activities although most of these reports are of academic interest and very few find entry in clinical trials. The present review is...
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