Posted by admin on Apr 30, 2020 in |
Background: Swertia chirayita (Roxb. ex Flem.) Karsten known as Kiratatikta in Ayurveda, the Indian indigenous health system, is used for various ailments like liver disorders, diabetes, fever, worm infestation, and others. Due to huge demand and non-availability, other Swertia species and other herbs are used as substitutes/adulterants for Swertia chirayita (Roxb. ex Flem.) Karsten. Hence, the present study is carried out with the objective of characterizing the macroscopic, microscopic features, the physicochemical and chromatographic profile of the herb. Material & Methods: Pharmacognostical parameters like microscopy, physico-chemical, phytochemical and chromato-graphic investigation for the whole plant of Swertia chirayita (Roxb. ex Flem.) Karsten was done using standard methodology. Results: The chief macroscopic features of the whole plant are wrinkled roots, quadrangular stem in the upper portion, leaves brittle, and presence of flowers and fruits. In powder microscopy, fragments of the epidermis with stomata, resin containing cells, pitted parenchyma, cells forming epidermis of fruit, parenchyma cells, pitted fibers, fragments of cotyledon, endosperm cells, sclereids were the key features. Phytochemical analysis revealed the...
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Posted by admin on Apr 30, 2019 in |
The plant Withania somnifera has many acclaimed medicinal uses. This work aims to explore the efficacy of the aqueous extract (AE) of W. somnifera on the isolated trachea and aorta rings, perfused heart, blood pressure and diuresis in rats. Phytochemical analysis of the whole plant of W. somnifera was carried out using standard extraction procedures followed by column chromatography. An aqueous extract (AE) was also prepared by boiling the whole plant material in water followed by evaporation under reduced pressure. The smooth muscle relaxant effect of AE of W. somnifera (10-4 – 3×10-1 mg/mL) was tested on isolated rat tracheal and aortic rings. The effect of AE on heart rate and contractility of the isolated perfused heart were recorded. The hypotensive effect of AE (0.4-120 mg/kg) was recorded from the carotid artery in anesthetized normotensive rats. The diuretic activity of AE was evaluated in rats at two different doses (800 and 1600 mg/kg), and urine volume was measured throughout 24 h. Phytochemical analysis of the Jordanian locality of W....
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Posted by admin on Apr 30, 2019 in |
The present investigation was directed to assess the counter lithiasis action of ethanolic concentrates of entire plant of Bryophyllum pinnatum. Urolithiasis is an infection brought about by the nearness and impacts of uroliths (stones) or calculi or exorbitant measures of precious stones in the urinary tract. The illness is alluded to by numerous names, including cystitis, urethritis, urinary calculi, bladder stones, or kidney stone. Ethanolic concentrate of the plant of Bryophyllum pinnatum was exposed to antilithiatic action in rodents where Ethylene glycol (0.75 (v/v)) utilized as the causing lithiasis specialist. A stamped ascend in calcium, oxalates, phosphorus, and creatinine in blood serum level saw in lithiasis (100 and 200 mg/kg) displayed a portion subordinate critical enemy of lithiasis action on treatment. The concentrate portion of 300 mg/kg likewise caused fractional instruction of calcium, oxalates, phosphorus, and creatinine in blood serum level the outcomes were discovered factual irrelevant. The antilithiatic impact of ethanol separate was discovered compelling with that reference...
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Posted by admin on Apr 30, 2019 in |
Diabetes mellitus is a metabolic disorder in which blood glucose level decrease. Due to this disease, various complications are arises including retinopathy, nephropathy, cardiovascular disease, and neuropathy. Diabetes mellitus is a chronic condition includes Type 1 DM, Type 2 DM and gestatational diabetes, which occurs in pregnancy. For the management of DM various system of medicine is used, from that herbal or traditional medicine is used for many cases as a core medicine or supplementary to allopathic medicine. Frequency of occurrence of type 2 DM is high than type 1 DM. Different type of plant or herbal extract are used for management of DM includes, Ocimum sanctum, Allium stivum, Eugenia jambolana, Abelmoschus esculentus, Allium cepa, Gymnema sylvestre, Momordica charantia, Pterocarpus marsupium etc. Many plants are use as single herb extract for treatment or used in combination with other anti-diabetic plants as a poly herbal...
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Posted by admin on Apr 30, 2019 in |
Aim: The present research aims to screen anabolic activity on bone formation and bone density in normal and Teriparatide (Rh PTH biosynthetic human parathyroid hormone 1-34) induced inhibition of osteogenesis in zebrafish larval model to alleviate osteoporosis and other bone and joint disease or disorders of the Nano encapsulated essential oil isolated from the Ruta graveolens (NELVORG) Family: Rutaceae using a novel, fast, economical and genetically tractable method for screening developmental aspects of bone formation in a high throughput fashion through the visualization of embryonic and larval skeleton of zebrafish (Danio rerio) model. Method: The volatile oil (VO) was isolated from the leaves of R. graveolens and extracted VO was subjected to GC-MS Analysis. The nano-encapsulated volatile oil of R. graveolens leaves (NELVORG) was prepared by solvent displacement method, and particle size was standardized by scanning electron microscope (SEM). We implemented 3Rs (Reduction, Replacement, Refinement) ethical principle to minimize harm to the vertebrate animals. Preliminary toxicological studies were evaluated on whole embryo and larvae, showed no mortality up to...
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