Posted by admin on Mar 31, 2019 in |
Ajuga chamaepitys (L.) Schreb, well-known as Camaepitiumor Ground Pine, is an annual herb typical of the Mediterranean area accounting several uses in the traditional medicine. In this study, the methanol extract of Ajuga chamaepitys (L.) Schreb was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS), while the mass spectra of the compounds found in the extract were matched with the National Institute of Standards and Technology Library. The study revealed the presence of fifteen phytocomponents. The most abundant compounds in the methanol extract were eucalyptol, thujone, endoborneol, davana ether, and octacosane. The results indicated that polarity of the solvents used in extraction influenced the relative abundance and type of compounds extracted. The various compounds identified are known to have varying bioactivities such as being hemorrhoids, stomachache, jaundice, and inflammatory diseases....
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Posted by admin on Mar 31, 2019 in |
Cancer is the one of the leading cause of death worldwide. Even though many treatments exists in treating and controlling the progression of the deadly disease cancer, yet important inadequacy for development remain. Several undesired side effects occur when cancer is treated using chemotherapy. Therapies of Mother Earth, that utilizes bioactive products derived from a plant in treating cancer, may lessen the side effects. North-East India is recognized as a rich ethnomedicinal asset. It contributes to the abundant reservoir of plant diversity and is recognized as one of the ‘biodiversity hotspots’ of the world reinforcing around 50% of the country’s biodiversity. There has been an increasing frequency of occurrence of cancer in developing countries like India, Nepal, and Pakistan which has serious implications on the morbidity and mortality in millions of people. Most of the Himalayan plants that have been reported are biologically active against different cancer types. The present statistics of cancer chemotherapy is bleak which is why there is an urgent need to develop and discover potent...
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Posted by admin on Mar 15, 2018 in |
The aim of the present study to evaluate the anti-diabetic activity of methanolic extract n-butanol fraction of Curculigo orchioides (Amaryllidaceae) against in streptozotocin-induced diabetic rats. Fractions were administrated orally at 200 mg/kg and 100 mg/kg for 3weeks. The effects were compared with an oral dose of 10 mg/kg of glibenclamide. Blood glucose levels are a determination by GOD-POD kit method. In the results, our study indicates that Curculigo orchioides n-butanol fraction of leaf methanolic extract exhibited significant antihyperglycemic activities in streptozotocin-induced hyperglycemic rats without significant change in body weight. And shows the values are given in average body weight (g) ± SEM for groups of six animals each. A) Normal saline. B) Normal saline + streptozotocin. Significance vs. Control group *P < 0.01. **P < 0.005, ***P <...
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Posted by admin on Mar 15, 2018 in |
The present study was designed to evaluate the in vitro antioxidant effects and potential benefits of using coconut kernel extract in preventing the proliferation of human breast cancer cell line, MCF-7. Defatted extract from coconut kernel (CKf) was evaluated for its radical scavenging, prevention of human LDL oxidation, cytotoxic, apoptotic and nuclear effects on MCF-7 cells. Intracellular production of reactive oxygen species (ROS) and superoxide radical was studied. It was showed that CKf significantly scavenged free radicals and prevented LDL oxidation. MCF-7 cell viability was found to be decreased in a dose-dependent manner following treatment with CKf. AO-EB and DAPI staining confirmed that treatment with CKf, induced nuclear damage and apoptosis as distinctly visualized in cells. Our observations suggest that nuclear/cellular damage and poor mitochondrial membrane potential (MMP) appears to be an indirect consequence of the excessive generation of reactive oxygen species (ROS) and superoxide...
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Posted by admin on Mar 15, 2018 in |
Disturbance in retinal blood supply can have an effect on the supply of oxygen and the substrates which leads to retinal ischemia, the result is irreversible, ischemic and apoptotic cascades resulting in cell death. The present study was conducted to study the protective effects of diltiazem and vitamin E “alpha-tocopherol,” against degenerative ischaemic retinal changes induced by Middle Cerebral Artery Occlusion (MCAO) in rabbits. Animals were classified into normal control group which received tap water throughout the experiment, positive control where induction of retinal ischemia was done by MCAO and three treated groups: a group received diltiazem (15 mg/kg), another received vitamin E (200 mg/kg body), and a third received both diltiazem and vitamin E for three successive weeks followed by induction of retinal ischemia by MCAO for all treated groups. When assessment of the protective effects of diltiazem and vitamin E and their combination, was done by clinical examination of the eyes, measurement of reduced glutathione, malondialdehyde and nitric oxide levels, electroretinography and histopathologically, it showed that both...
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