Posted by admin on Feb 1, 2015 in |
Peptic Ulcer Disease (PUD) is an inflammation along the mucosal lining of esophagus, stomach or duodenum or anywhere in the gastrointestinal tract. PUD is the most common gastrointestinal disorder in clinical practice because of alteration in lifestyle and food habits. The main symptoms related to PUD are Indigestion, heartburns, burning pain or abdominal pain, nausea, vomiting, constipation, bloating of stomach and abdomen, not feeling of well in both body and mind. In severe cases, symptoms can be dark or black stool (due to bleeding), vomiting blood (look like “coffee-grounds”), Weight loss, and severe pain in the mid to upper abdomen. The most important complications are Hemorrhage, Bleeding, Perforation (a hole through the wall of the stomach), Gastric outlet obstruction, if not treated properly. The drugs like Antacids, H2 Receptor antagonist and Proton pump inhibitors are used for PUD all around world widely to relieve the symptoms by the allopathic medicine side. Many of Medicinal plants are used for their anti-ulcer, anti-secretory & Gastro-protective property by the practitioners of herbal...
Read More
Posted by admin on Jan 1, 2014 in |
Studies on anticancer and protein inhibition process play a vital role in regulating the cellular process of life and diseases. The present studies have been conducted on ethanolic tuber extract from Globba bulbifera for protease inhibition and breast cancer inhibition. The extract has shown good inhibition for Trypsin, Chymotrypsin and protease K. The extract has also shown MCF-7 (Breast Cancer) inhibition, IC50 value at 235 μg/ml. The inhibition is less compared to the standard compound, tamoxifen (IC50: 37 μg/ml). Hence the present studies have shown good protease inhibition and anticancer (breast cancer)...
Read More
Posted by admin on Jan 1, 2014 in |
Marine macroalgae Sargassum is commonly referred to as brown seaweeds. Commercially and continuously the pharmaceuticals industries are rapidly growing because always demand for new drug discovery is encouraged. Since, brown seaweeds have ample source of bioactive compounds of primary or secondary metabolites. These potential bioactive compounds interest to improve the pharmaceuticals industry. This present study was investigated to explore the antibacterial and antifungal activity of the organic solvents of the brown seaweed Sargassum. Phytochemical analysis of Brown seaweeds of Sargassum longifollium with six different organic solvents was analyzed. All the solvents like Dimethyl Sulfoxide (DMSO), Benzene, Acetic acid, hexane, Di Ethyl ether, and Chloroform has the extraction of phytochemical constituents. Among the six solvents, Dimethyl Sulfoxide (DMSO) extract showed a maximum number of phytochemical constituents and antibacterial and antifungal activity when compared to other five solvent extracts. FTIR identified the responsible functional groups in the solvent extract. These results statements be a necessary (or) recommended that the species of brown seaweeds (Sargassum longifolium) having a potential capacity as a...
Read More
Posted by admin on Jan 1, 2014 in |
Our ecosystem is laden with hazardous and non-hazardous wastes that pose a serious threat to bio-existence. Most pharmaceutical formulations contain chemically-synthesized surfactants. The purpose of this work is to suggest an alternative source of surfactant which would also aid in ridding our environment of harmful wastes. Bacillus licheniformis B-4 strain isolated from a hydrocarbon dump site produces biosurfactant with excellent interfacial properties utilizing unconventional substrates (kerosene and diesel) as carbon sources, and glucose as an energy source. Acid precipitation and foam separation methods were used for biosurfactant recovery and its physicochemical properties evaluated which include the effect of the biosurfactant on the surface tension of water, critical micelle concentration (CMC), emulsification stability (ES) of kerosene and diesel, emulsification index, hemolytic activity, and antimicrobial activity. The results showed that the biosurfactant reduced the surface tension of water from 70.2 to 14.7 Nm-1, CMC was estimated to be 50 mg/l, emulsification stability of kerosene and diesel were obtained as 0.06 and 0.02 min-1, while the emulsification indices were 72.2 and 50...
Read More
Posted by admin on Jan 1, 2014 in |
Ocimum basilicum L. and Ocimum gratissimum L. (Lamiaceae) are widely distributed aromatic herbs used in ethnomedicinal management of a range of inflammatory disorders. In the present work, we evaluated the topical anti-inflammatory effects of the volatile constituents extracted from the fresh leaves of these plant species. Fresh leaves of the plants were subjected to hydro distillation to obtain the volatile oils OBV and OGV from O. basilicum and O. gratissimum respectively. The fresh leaves were also extracted with n-hexane to obtain OBHE and OGHE respectively. OBV, OGV, OBHE, and OGHE were screened for anti-inflammatory effect using xylene-induced ear edema as a model of inflammation. Their chemical constituents were also analyzed using GC/MS apparatus. At 50 µg/ear OBV, OGV, OBHE and OGHE exhibited significant (P<0.05) topical anti-inflammatory effect with edema inhibitions of 50.0, 63.3, 62.7 and 80 % respectively. The effects were comparable (P<0.05) with that of 100 µg/ear hydrocortisone (% edema inhibition of 54.8). 11 of the compounds from OGV are monoterpenes while 4 are sesquiterpenes. 8 of the...
Read More