EVALUATION OF THE ANTI-UROLITHIASIS POTENTIAL OF AYURVEDIC MARKETED FORMULATION IN EXPERIMENTAL ANIMAL MODELS
AbstractUrolithiasis is a common urinary tract disorder characterized by the formation and retention of urinary calculi, predominantly composed of calcium oxalate. The present study evaluated the anti-urolithiatic potential of Go-Pathri, an Ayurvedic marketed formulation, in experimental rats. Male Wistar albino rats were divided into five groups (n=6). Urolithiasis was induced using 0.75% ethylene glycol, followed by treatment with Cystone (750 mg/kg) or Go-Pathri (50 and 100 mg/kg) for 14 days. Urine volume, urinary calcium, oxalate, phosphorus and magnesium, and serum uric acid, creatinine and BUN were evaluated. Histopathological examination of renal tissues was also performed. Ethylene glycol produced marked alterations in urinary and serum biochemical parameters and promoted renal calcium oxalate deposition. Go-Pathri treatment improved urine output, reduced urinary stone-forming constituents and serum uric acid, creatinine and BUN levels, and reduced renal crystal deposition. The 100 mg/kg dose showed greater improvement than 50 mg/kg. These findings demonstrated the potential anti-urolithiatic and renoprotective effects of Go-Pathri.
Article Information
5
1027-1036
1123 KB
9
English
IJP
Mohd Adil Ansari *, Rohit Kumar Bijauliya, Pushpendra Kannojia, Pankaj Kumar Shankhdhar and Anita Yadav
BIU College of Pharmacy, Bareilly International University, Bareilly, Uttar Pradesh, India.
adilansari5952@gmail.com
15 September 2026
29 September 2026
30 September 2026
10.13040/IJPSR.0975-8232.IJP.13(10).1027-36
01 October 2026
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