FORMULATION AND EVALUATION OF ANTIDIABETIC POLYHERBAL SYRUP
AbstractThis study investigated four medicinal plants Moringa oleifera leaves, Hippophae rhamnoides (Sea buckthorn) berries, Syzygium cumini seeds, and Psidium guajava leaves for their suitability in developing a polyherbal antidiabetic syrup. Hydroalcoholic extracts were prepared through maceration and yielded diverse phytochemical constituents, including flavonoids, alkaloids, saponins, glycosides, tannins, and phenols. Among the plants, Syzygium cumini exhibited the richest phytochemical profile, while Sea buckthorn uniquely contained terpenoids and steroids. Three syrup formulations were evaluated and found to possess acceptable physicochemical properties, with Formulation 2 demonstrating optimal viscosity, pH, and palatability. In-vitro antidiabetic analysis showed that all extracts inhibited α-amylase, while Syzygium cumini and Moringa oleifera demonstrated dual inhibition of α-amylase and α-glucosidase, though with higher IC₅₀ values than Acarbose. Overall, the results support the potential of these plants particularly Syzygium cumini for use in a synergistic polyherbal syrup aimed at managing diabetes through digestive enzyme inhibition. Further in-vivo and clinical investigations are recommended to confirm efficacy and safety.
Article Information
9
126-131
488 KB
7
English
IJP
Anil Verma *, M. Himaja Trivedi and Satendra Sharma
Shri Ramnath Singh Institute of Pharmaceutical Science & Technology, Sitholi, Gwalior, Madhya Pradesh, India.
rkpharma3791@gmail.com
31 January 2026
25 February 2026
26 February 2026
10.13040/IJPSR.0975-8232.IJP.13(2).126-31
28 February 2026
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