WOUND HEALING AND IN-VIVO ANTIOXIDANT ACTIVITY OF MIMUSOPS ELENGI LINN. LEAF EXTRACT

Objective: Phytochemical and pharmacological investigation on the leaves of Mimusops elengi Linn. for wound healing and in-vivo antioxidant activity in albino mice. Material and Methods: The methanolic extract of leaves of Mimusops elengi was studied for its wound healing effect on excision wound model in mice and in-vivo antioxidant activity at the dose level using a biochemical estimation of blood serum in mice. Result: Preliminary phytochemical analysis revealed the presence of saponin, carbohydrate, glycosides, flavonoids, tannin and phenolic compounds. Mimusops elengi methanolic extract (MEME) was examined for wound healing activity in the form of ointment in excision wound model in mice. The extract ointment showed a considerable response in the above model as compared to standard drug Betadine ointment regarding wound contracting ability, wound closure time. Histological analysis was also consistent with the proposal that Mimusops elengi leaf extract exhibits significant wound healing effect. As antioxidant action has been reported to play a crucial role in the hepatoprotection in in-vivo model of antioxidant activity. It has been found that it reduces both serums ALP and Bilirubin. Treatment with CCl₄ increases the level of total lipid, total triglycerides and total cholesterol in the liver which was reduced on the administration of a methanolic extract of Mimusops elengi. Conclusion: The methanolic extract possesses wound healing and in-vivo antioxidant activity.