COMPARATIVE NEUROPROTECTIVE POTENTIALS OF THE EXTRACTS OF TALINUM TRIANGULARE AGAINST NITROPRUSSIDE-INDUCED DAMAGES IN ALBINO RATSAbstract
The inhibitory effects of ethyl acetate, aqueous and ethanolic extracts of Talinum triangulare were well observed in the brain homogenate of swiss albino rats against sodium nitroprusside induced-peroxidation by thiobarbituric acid reactive species (TBARS) in-vitro. All the extracts showed significant inhibitory abilities against sodium-nitroprusside (SNP) induced lipid peroxidation in the brain homogenate when incubated with 60mM sodium nitroprusside. In the current work, aqueous extract of Talinum triangulare seems to possess higher antioxidant contents with the fact that it shows the highest inhibition potential against SNP-induced peroxidation in the brain tissue homogenate from the results, thereby characterize the ability to protect the brain cell and as well able to prevent nitrosative stress induction at considerable measure in the brain.
O. Bafolabi * and O. Ioloyede
Biochemistry Unit, Department of Chemical Sciences, College of Science, Afe-Babalola University, P.M.B 5454, Ado-Ekiti, Ekiti State, Nigeria.
11 September, 2014
21 October, 2014
29 October, 2014
01 November, 2014