Posted by admin on Jul 31, 2024 in |
In Ivory Coast, the leaves of Ipomoea batatas are consumed like spinach without any prior study of toxicity. This study aims to evaluate the toxicity of Ipomoea batatas leaf macerate on female rats. Thus, the phytochemical screening, the acute oral toxicity test of the leaf macerate of this plant was carried out on female rats. The results show that Ipomoea batatas leaves contain sterols and polyterpenes, polyphenols, flavonoids, alkaloids and saponosides. The study also reveals that the macerate of I. batatas leaves is not toxic orally. The rats showed no signs of toxicity. The weight of vital organs of female rats treated with the macerate showed no significant difference from that of control female rats. Concerning the reproductive organs, a significant increase in the weight of the ovary was observed in females’ rats treated with the extract compared to control rats. The study revealed a decrease in the level of white blood cells in the test female rats. At level of biochemical parameters, a significant decrease in AST and...
Read More
Posted by admin on Jul 31, 2024 in |
The computer-aided drug design (CADD) symbolizes an intricate discipline exploitation accomplishment in varied areas of science and varied strategies and approaches. It tends to speed-up and optimize discovery of latest biologically active compounds. However, these approaches cannot replace the experimental tests. The aim of CADD is to generate hypotheses regarding probable new ligands and their interaction with targets. It’s considered that these strategies will decrease the quantity of the compounds that are required to be synthesized and tested for biological activity up to 2 orders. Thus, they’re capable to decrease basically time consuming monetary expenses for development of medicine. A Recent terribly effective technique in era is drug designing through computers. CADD technologies are employed in technology, biological science, organic chemistry etc. The main advantage of the CADD is value effective in analysis and development of medicine. There are wide ranges of software that are employed in CADD, Grid computing, window primarily based general PBPK/PD modeling computer software, PKUDDS for structure based drug design, APIS, JAVA, Perl and Python....
Read More
Posted by admin on Jul 31, 2024 in |
Dissolution of drug and its release from the dosage form have basic impact on bioavailability. The solubility of a medication determines its bioavailability. As new medications are developed, solubility becomes a significant concern for the pharmaceutical industries. About 40% of recently developed medications fit into the poor water soluble or water insoluble classifications. Generally speaking, weakly water-soluble medications have an aqueous solubility of less than 100μg/ml. There are numerous ways to improve the solubility of poorly soluble medications, and one particularly effective method is the use of liquisolid compacts. A unique idea for a novel drug delivery system (NDDS) that can speed up the rate at which water-insoluble medications dissolve is the liquisolid compact system. The basis of this liquisolid method is the dissolution of the insoluble drug in a non-volatile solvent, followed by the mixing of drug-loaded solutions with suitable carriers and coating materials to produce powders that flow and compress into acceptable levels. These free-flowing powders are compressed to make tablets or filled in...
Read More
Posted by admin on Jul 31, 2024 in |
Cancer is a disease of cells where uncontrolled proliferation occurs leading to death of the incumbent. There is no effective vaccine for prevention and prophylaxis of cancer. Currently available anticancer allopathic drugs have a lot of disadvantages including frequent recurrence of the disease. In this perspective, nature could be a good alternative source of anticancer herbs and phytoconstituents that may prevent the proliferation of cells and even cure the cancer. This review summaries such herbs and phytoconstituents that could give good preventive and prophylactic effect as anticancer...
Read More
Posted by admin on Jul 31, 2024 in |
Common kinds of chemotherapy may cause harm to normal cells and tissues. Localised chemotherapy, unlike systemic chemotherapy, can lessen side effects by providing a consistent supply of chemotherapeutic chemicals directly to the tumour location. This emphasises the importance of controlled-release biodegradable hydrogels as chemotherapeutic drug delivery systems. This study looks at employing hydrogels as drug delivery methods for HCC, including thermosensitive, pH-sensitive, photosensitive, dual-sensitive, and glutathione-responsive hydrogels. Hydrogel-based drug delivery systems outperform traditional systemic chemotherapy in cancer treatment. Cancer immunotherapy has emerged as the new paradigm for cancer treatment. The development and discovery of new therapeutic molecules has increased the use of immunotherapy in clinical studies. This article discusses the current state of functional hydrogels for effective cancer immunotherapy. First, we will discuss the fundamental principles of cancer immunotherapy and the benefits of employing hydrogels to implement these mechanisms. Finally, we briefly explore the existing issues and potential applications of hydrogels for effective cancer...
Read More
