Posted by admin on Jan 31, 2024 in |
Objective: Major Depressive Disorder (MDD) is a psychological disease with a growing global burden. Oxidative stress has been shown to be a causative mechanism of MDD. This research aimed to evaluate the effect of antioxidant-rich fruits (mango, carrots and watermelon) on oxidative stress markers in rats treated with Dexamethasone to induce depression. Method: Thirty (30) rats were grouped into 5: Group 1 (positive control), Group 2 (treated with 2.6 mg/kg body weight Dexamethasone only), Group 3 (treated with 2.6 mg/kg b.w. Dexamethasone and 10.53ml/kg b.w. of watermelon juice), Group 4 (treated with 2.6 mg/kg body weight Dexamethasone, and 10.53ml/kg b.w. of carrot and mango juice) and Group 5 (treated with Gingko Biloba). The lipid profile and C-reactive protein (CRP) were determined using blood samples. Brain homogenate was used to determine oxidative stress parameters SOD, GPx, GSH, MDA, and serotonin levels. Results: Results of the research showed a significant increase in HDL and a significant decrease in LDL, TAG and MDA levels in Group 4. A significant increase was observed...
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Posted by admin on Dec 31, 2023 in |
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptane-3,5-dione) is a hydrophobic polyphenol derived from the roots of the Curcuma longa and is also known as diferuloylmethane (C12H20O6). It shows various pharmacological effects like anti-inflammatory, anti-oxidant, anti-carcinogenic, chemo-preventive, anti-diabetic, anti-viral, and anti-bacterial in spite of these curcumin is still far away from the clinical uses due to their low bioavailability and in which is related by the poor absorption, quick metabolism, poor water solubility, and chemical instability as a diet-derived agent curcumin has been used traditionally in many forms for the treatment of inflammation and pain but most of the recent studies uncovered the role of curcumin as an antidiabetic, anti-carcinogenic, anti-infectious, antidepressant and antipsychotic agent. This dietary supplement has ability to block a number of cells signaling pathways at various levels underlies its diverse effect. By modulating cell cycles and interacting directly to molecular targets like glutathione peroxidase, nuclear factor kappa-B cells, cyclooxygenase-2, hepatic superoxide dismutase, reactive oxygen species tumor necrosis factors etc. curcumin can prevent the development of cancer. In this chapter, we demonstrated...
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Posted by admin on Dec 31, 2023 in |
Clinical studies have demonstrated the benefits of herbs and herbal oil for hair growth. The primary issues linked to hair loss include dandruff, hair fading, and hair falling out, which are issues that both men and women find quite concerning. There are some synthetic medications for hair loss which exhibit serious adverse effects in addition to not providing an effective cure. The primary goal of this work is to create a herbal hair oil formulation that can address hair loss and other hair-related issues. Herbs like Murraya koenigii, Lawsonia inermis, Azadirachta indica, Vitex negundo, Phyllanthus emblica, Centella asiatica, Hibiscus rosa sinensis cederwood oil and Rosmerry oil were selected for the formulations of hair fall control herbal hair...
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Posted by admin on Dec 31, 2023 in |
Lupeol, a pent acyclic triterpenoid known as secondary metabolites. Chemically it is a 20(29)-Lupen-3-beta-ol derived from eggplant. The main part of this plant is steam & bark. It is obtained from vegetables, fruits & medicinal plants. The isolation of Lupeol was done by TLC monitoring column chromatography by using solvents like hexane & ethyl acetate on the basis of adsorption principal. The species of Lupeol such as S. xanthocarpum which have specifically anti diabetic action & many other species which have a dynamic and diverse effects. The doses of Lupeol vary from disease to disease and it can be administered in-vitro & in-vivo technique like intra-peritoneal, intramuscular, oral, topical. On the basis of many researches’, Lupeol shows a magical activity toward various types of diseases with less side effects & have a good ability to cross blood brain...
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Posted by admin on Dec 31, 2023 in |
Background: Diabetes mellitus, or simply diabetes, is a set of endocrine ailments characterized by persistently elevated blood sugar levels. Diabetes is caused by either the pancreas not making enough insulin or the body\’s cells becoming resistant to the hormone\’s effects. Thirst, polyuria, weight loss, and impaired eyesight are common indications of Diabetes. Combining herbal therapy seems to be beneficial in the treatment of type 2 diabetes and related issues. Aim: The goal of the current research was to formulate a polyherbal anti-diabetic formulation using Withania coagulans, Emblica officinalis, and Trigonella foenum-graecum. Method: Material like pulverized powder of Trigonella foenum-graecum Linn, Withania coagulans Dunal, and Emblica officinalis were used in the present study for phytochemical screening, tablet punching, and in-vitro study along with the flow properties of Polyherbal granules. Polyherbal tablets were used in the in-vitro antioxidant DPPH experiment and the in-vitro anti-diabetic effect was examined using alpha-amylase enzyme inhibitory activity. Result: The flow properties of the developed Polyherbal granules were remarkable. In an in-vitro investigation, polyherbal tablets were examined...
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