Posted by admin on Nov 6, 2016 in |
Natural products and herbal remedies used in traditional folklore medicine have been the source of many medically beneficial drugs because they elicit fewer side effects, relatively cheap, affordable and claimed to be effective. However, in order to make these remedies acceptable to modern medicine, there is a need to scientifically evaluate them to identify the active principles and to understand their mechanism of action. Tephrosia villosa Pers. (Fabaceae) is a medicinal plant widely used as a folk medicine in India. The present study deals with the isolation and partial purification of bioactive compounds from the crude methanol extracts of the leaves of Tephrosia villosa Pers. The quantification and the identification of compounds in the crude extract and active bands isolated by preparative TLC were accomplished using spectroscopic analysis. The most important compounds β-sitosterol identified in the crude extract appreciable amounts may account for its various biological...
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Posted by admin on Nov 6, 2016 in |
The present study aims to standardize Amritarishta based upon chromatographic and spectral studies. The spectral data and HPTLC fingerprint of ethanolic extract of Amritarishta could be used as a valuable analytical tool in the routine standardization of Amritarishta to check the batch to bath variation. Fraction, I and II of ethanolic extract of Amritarishta and standard luteolin and apigenin, were compared by TLC, HPTLC, and HPLC analysis to evaluate the presence of luteolin and apigenin is employing toluene: ethyl acetate: glacial acetic acid (5:4:1 v/v/v), as a mobile phase respectively. The Rf values (0.64) and (0.81) for luteolin and apigenin in both sample and reference standard were found comparable under UV light at 366 nm respectively. The High-Performance Thin Layer Chromatography method developed for quantization was simple, accurate and specific. The present standardization provides a specific and accurate tool to develop qualifications for identity, transparency, and reproducibility of biomarkers luteolin and apigenin in a liquid...
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Posted by admin on Nov 6, 2016 in |
In the present day world the consumption of fruits, vegetables and natural diet for the prevention of certain diseases, in addition to their nutritional benefits is increased. Jack fruit is well known for its nutritional and therapeutic qualities for many years. The present communication deals on the macroscopical, microscopical, powder microscopical studies along with the preliminary phytochemical studies on the seeds of Artocarpus heterophyllus Lam. belonging to the family Moraceae. The study revealed the presence of abundant simple to compound starch grains and oil globules in the cotyledon region; powder study revealed the presence of abundant starch grains, spiral to helical xylem vessels, stone cells with broad lumen with the highly lignified wall, orange colored cork cells in surface view. Phytochemical studies revealed the presence of carbohydrates, proteins, starch, flavonoids, saponins, phenols and alkaloids. Seeds are rich in protein, highly nutritious and have numerous culinary uses; starchy flour is also made out of...
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Posted by admin on Nov 6, 2016 in |
Extensive studies have been carried out in the last decade to assess the pharmaceutical potential and screening of the phytochemical constituent, psoralen. This component is found in many plants species and has gained attention nowadays because of its antibacterial, antifungal, antiviral, and anti-inflammatory properties. Psoralen is an active component of Babchi oil found in Psoralea corylifolia (P. crylifolia) belonging to family Leguminosae. This review presents an overview of the current status and knowledge on overview, chemistry, synthesis, analysis, irritation, and toxicity of psoralen. Also, formulations of psoralen are also presented here....
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Posted by admin on Oct 21, 2015 in |
In the present study, the photochemistry of fluoroquinolone antibiotic drug-besifloxacin (1) was investigated under mild conditions similar to those encountered in biological systems namely aerobic as well as an anaerobic condition with UV-A light. When besifloxacin (1) was irradiated with a high-pressure mercury lamp under aerobic conditions it afforded 7-(2-Amino-5-oxo-pentylamino)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo- 1, 4 – dihydro-quinoline-3-carboxylic acid as photoproduct (2) and under anaerobic condition it afforded 7-(3-Amino-azepan-1-yl)-1-cyclo propyl-6-fluoro-8-hydroxy-4-oxo-1,4dihydro-quinoline-3-carboxylic acid as photoproduct (3). The formation of photoproduct was explained by the type-I and type II mechanism of...
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