Posted by admin on May 31, 2021 in |
Objective: To investigate the Pharmacognosy as well as the Antioxidant, Anti-inflammatory potential of the Katha powder. Methods: The Coarsely dried chips of Acacia catechu heartwood were treated with 10% hydro-alcoholic solution to obtain Katha as the final product. The powdered Katha was standardized via pharmacognostic parameters. This Kathapower is showing good solubility in hot water, having astringent in the taste. The powder microscopy of the Katha powder is to be demonstrated fragments of acicular crystals, fibers and bordered pitted vessels. Katha powder antioxidant potential is to be accessed by using the DPPH assay and NO Scavenging assay by using ascorbic acid as a standard drug. Further, the Katha powder is to be subjected for the assessment of its anti-inflammatory potential by use of Heat-induced hemolysis as well as the Hypotonicity-induced hemolysis approach by the use of aspirin or diclofenac sodium as a standard drug. Results: Microscopical investigations were showed that Katha showing the presence of fragments of acicular crystals, fibers, and bordered pitted vessels. In-vitro study shows that the...
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Posted by admin on May 31, 2021 in |
The spread of infectious diseases in the world is a major challenge for health institutions and pharmaceutical industries. The current trends of multi-drug resistance to the available synthetic drugs or antibiotics among emerging and re-emerging bacterial pathogens lead to serious risks. It is therefore necessary to search for new antimicrobial agents that are better, cheaper and without side effects for treating these infectious diseases, especially in developing countries. In this study, phytochemical composition and antimicrobial activities of aqueous and methanol extracts of stem-barks of Mangifera indica were investigated. Standard methods were employed to screen for the presence of phytochemicals. Agar well diffusion method was used to determine the antimicrobial effects of aqueous and methanolic extracts of M. indica stem-bark against selected bacterial (Shigella sp, Staphylococcus sp, Escherichia coli, Vibrio sp) and fungi (Penicillium sp, Yeast, Mould) isolates. Phytochemical results showed the presence of active pharmacological components such as tannins, saponins, glycoside, flavonoid, terpenoid, alkaloids, and steroid. Methanol extract demonstrated the highest activity of bacterial (Staphylococcus sp with 15.4 ±...
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Posted by admin on May 31, 2020 in |
Treatment based on traditional medicine is very popular in the developing world due to inexpensive properties. There is a growing interest in herbal medicine. Curcumin a hydrophobic poly-phenol is derived from turmeric, the rhizome of the herb Curcuma longa L. Neurodegenerative diseases have become a major challenge for public health because of their incurable status. Curcumin has an outstanding safety profile and a number of pleiotropic actions with potential for neuroprotective efficacy, including anti-inflammatory, antioxidant, and anti-protein-aggregate activities. Because of its pleiotropic actions on the central nervous system, including preferential binding to amyloid proteins, Curcumin is being touted as a promising treatment for age-related brain diseases. This review article aims at gathering information predominantly on neurodegenerative...
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Posted by admin on May 31, 2020 in |
Salacia chinensisis, commonly known as Saptarangi in the Hindi family of Hippocrateaceae, it is a woody climbing shrub found in Africa, Vietnam, and Thailand. A large number of biologically active compounds like salacinol, kotalanol, neokotalanol, neosalacinol, salasol, and mangiferin are isolated from S. chinensis. Traditionally, the plant is used in the treatment of diabetes, but there are few studies that demonstrate its use as anti-inflammatory, nephroprotective, anticancer, and treatment of cardiac disorders. The present study involves extraction, isolation, structural elucidation, and prediction of antioxidant activity from the roots of S. chinensis. The roots were extracted with water and methanol by using a hot extraction method. The methanol extract was fractionated with ethyl acetate. The antioxidant activity of different extracts was determined by 1, 1-diphenyl-2- picryl- hydrazyl (DPPH) method. The highest antioxidant activity was found in ethyl acetate extract, followed by methanol extract and water extract. Ethyl acetate extract showed maximum antioxidant activity, so the extract was used for the isolation of antioxidant compounds by column chromatography. The compound was...
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Posted by admin on May 31, 2019 in |
The role of surfactants is very critical in the development of pharmaceutical formulations. The diverse applications in different delivery systems have been highlighted in different reports of formulation development for various conventional and advanced delivery systems. The relevancy of critical micelle concentration and HLB value for the section of surfactants for different drug delivery systems was rationalized with suitable examples. The present attempt is focused on the compilation of all the important aspects of surfactants with a broad discussion on the drug delivery implications. The regulatory status of different investigational surfactants has been criticized relevantly with a compilation of FDA approved surfactants. The safety aspects of newly developed surfactants must be ensured before their incorporation in therapeutic dosage forms. The properties of different categories of surfactants were discussed with special emphasis on their physicochemical properties. The compiled information will make a firm base for the selection of surfactants for conventional and advanced drug delivery systems. Precise information on surfactant toxicity was also included to give a check to the...
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