Posted by admin on Jan 31, 2019 in |
Considering the prevalence of epilepsy and the problems associated with currently available antiepileptic drugs like side effects, resistance, safety issues and high cost, herbal medicines with fewer complications could be very appropriate alternative. Therefore, in the present study, we have examined the antiepileptic properties of ethanolic extract of Rhododendron arboreum leaves in mice using maximal electroshock seizure (MES) test, Pentylenetetrazole (PTZ) induced seizures, Strychnine induced convulsion and brain amine estimation method. The ethanolic extract at 200 mg/kg and 400 mg/kg possess dose- dependent anticonvulsant activity as it reduced the duration of seizures produced by maximal electroshock and delayed the latency of seizures produced by PTZ and Strychnine. The amount of Dopamine and Nor-adrenaline which are most likely to be involved in seizure activity was increased in mice...
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Posted by admin on Jan 31, 2019 in |
Polyphenols are secondary metabolites found in all vascular plants. Red grapes are one of these plants rich in these substances. The main objective of this study was to trace the polyphenolic compounds profile of red grape leaves from various Western regions of Algeria and to study their antioxidant activity. A spectrophotometric assay of the main phenolic groups and a chromatographic assay by HPLC-DAD and HPLC-FLU were carried out. The screening of anti-oxidant power was also performed by phosphomolybdenum method and DPPH assay. The results showed that all the studied leaves samples are rich in phenolic compounds with differences from one region to another. Polyphenol contents varied from ± 246 ± 18.93 to 923 ± 88.06 mg Eq gallic acid/g.dw. The HPLC assay identified the polyphenolic compounds profile of the studied samples. The antioxidant activity was widely covered and highlighted; the leaves extract of Aïn Temouchent sample is the most active with an EC50 in the DPPH test of 0.08 mg/mL, which is higher than EC50 of ascorbic acid. This...
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Posted by admin on Jan 31, 2019 in |
Introduction: Infection due to antimicrobial resistance is currently one of the major threats to mankind. This study investigates the antimicrobial activity of the various extracts of the stem bark of Maesobotrya dusenii (Pax) Hutchinson (Euphorbiaceae). Methods: Pulverized 100 g of stem bark of M. dusenii extracted with methanol. Another 400 g of the plant material was also successively macerated with n-hexane, ethyl acetate, and methanol. These extracts were assessed for antimicrobial activity on clinical isolates of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using agar diffusion method and minimum inhibitory concentration was determined. Ciprofloxacin was used as a standard antibacterial drug, while ketoconazole was used as a standard antifungal drug. Results: The ethyl acetate extract was the most active extract on E. coli with a minimum inhibitory concentration (MIC) of 0.025 mg/mL. The n-hexane extract also exhibited activity on E. coli with MIC of 0.196 mg/mL. Only n-hexane extract was active against Candida albicans with a MIC of 12.5 mg/mL. Conclusion: The ethyl acetate extract was active...
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Posted by admin on Jan 31, 2019 in |
Polygonum viscosum, belonging to the family Polygonaceae, is an annual herb which is highly distributed in Bangladesh, China, Nepal, Japan, and India. Like any other plant of the genus Polygonum, P. viscosum is significant from both phytochemical and pharmacological properties. Findings regarding the use of this plant in pain, fever, tumor, infection, inflammation, blood clots and so forth mark it as a valuable and noteworthy plant. According to our knowledge, there are very few studies presently available that document all the biological activities of P. viscosum. Hence, the following review gives a critical assessment of the literature to date and is the first review on the mentioned plant combining the limited research data found on Polygonum...
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Posted by admin on Jan 11, 2018 in |
Thevetia Peruviana (or Cascabela thevetia) belongs to the family Apocynaceae and commonly called as Yellow Oleander. The leaves of this significant medicinal plant were subjected to antibacterial investigation and HPLC analysis. Hexane, acetone, and methanol were used as organic solvents. Four different concentrations (200 mg/ml, 100 mg/ml, 50 mg/ml and 25 mg/ml) of each extract i.e. hexane, acetone and methanol were prepared for antibacterial activity by dissolving them in 100% DMSO. The leaf extracts were subjected to test the antibacterial activity by agar well diffusion method. The methanol extract of leaves showed significant antibacterial activity against Pseudomonas aeruginosa and poor activity against Micrococcus luteus and Shigella flexneri. Acetone extract showed moderate activity against the tested micro-organisms viz. Pseudomonas aeruginosa, Micrococcus luteus and Shigella flexneri. Hexane extract showed moderate activity against Micrococcus luteus and poor activity against Pseudomonas aeruginosa and Shigella flexneri at different concentrations. HPLC analysis of methanol leaves extract was performed which showed that plant leaf contains different types of phytosterols. Thevetia peruviana leaves a promising possibility of...
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