Posted by admin on Sep 30, 2025 in |
`Yastimadhuvati’ is a popular Ayurvedic formulation prescribed in cough, cold, respiratory diseases and chronic fever. The proposed study is aimed at developing physico-chemical parameters and estimating the contents of glycyrrhetinic acid and piperine in the formulation. Pills were prepared according to the Vaidyaka chikitsasar. The pills were subjected to pharmacognostical and phytochemical screening and evaluated for the standards visually, weight variation, friability and hardness tests. Further glycyrrhetinic acid was quantified by colorimetric method. Also a simultaneous HPTLC method was developed for quantification of glycyrrhetinic acid and piperine. The pills showed microscopical features like sclereids, crystal fibres, vittae, epidermis with subepidermis and oil glands. The acid insoluble ash was found to be 0.5 ± 0.61, Water soluble extractive value was higher than the alcohol soluble extractive value. The pills contained higher amounts of phenolics. The content of glycyrrhetinic acid was found to be almost same (0.4% w/w) when estimated by colorimetric and HPTLC methods. Piperine content was found to be 3.5%w/w using the same HPTLC method. The quality parameters developed...
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Posted by admin on Sep 30, 2025 in |
Medicinal plants remain an integral part of global healthcare systems, with nearly 70–80% of the population in developing countries relying on herbal remedies. Capparis divaricata Lam. (family: Capparaceae), a traditionally valued plant, has long been used as both food and medicine by various ethnic groups and practitioners of Ayurveda and Unani medicine. This review highlights the taxonomy, morphology, phytochemical profile, and pharmacological potential of C. divaricata. s. Pharmacological investigations report a wide spectrum of activities, including analgesic, antipyretic, antioxidant, anticancer, diuretic, CNS depressant, and antitubercular effects. Notably, ethanol and aqueous extracts showed potent inhibition of Mycobacterium tuberculosis, while chloroform and ethyl acetate extracts exhibited significant cytotoxicity against HeLa cancer cells. Collectively, available evidence suggests that C. divaricata is a promising medicinal resource with potential applications in drug discovery. However, detailed phytochemical isolation, mechanism-based studies, and clinical validation are essential to establish its safety and efficacy for future pharmaceutical...
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Posted by admin on Sep 30, 2025 in |
Bryophytes are known for chemically diverse group of non-vascular plants, and secondary metabolite of these plants, particularly in their lipophilic fractions yet remain unexplored in most of the plants. The present study deals with the analysis and investigation of the non-polar chemical composition of hexane extract of Bryum capillare using Thin Layer Chromatography (TLC) and Gas Chromatography-Mass Spectrometry (GC-MS) technologies. TLC revealed the different bands of presence of non-polar compounds and GC-MS analysis identified a range of hydrocarbons, fatty acids esters, terpenoids including diterpenes, triterpenes. These findings contribute to the scant phytochemical literature available on mosses and suggest the existence of non-polar bioactive compounds that may have therapeutic...
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Posted by admin on Sep 30, 2025 in |
Diabetic wounds represent one of the most challenging complications of diabetes mellitus, characterized by impaired tissue regeneration, prolonged inflammation, and high susceptibility to infection. Conventional therapies often fail to achieve satisfactory healing outcomes, necessitating the exploration of novel strategies. Probiotics, with their antimicrobial, immunomodulatory, and regenerative properties, have emerged as promising candidates for wound care. This study investigated the therapeutic potential of three commercially available probiotic strains Bacillus clausii (Enterogermina®), Lactobacillus sporogenes (Sporlac®), and Bifidobacterium longum (Florachamp®) incorporated into a PEG–glycerol-based gel formulation for topical application. The developed gels were characterized for physicochemical stability, spreadability, pH, and viscosity, alongside confirmation of probiotic viability. In vitro assays revealed variable antagonistic activity against Staphylococcus aureus and Pseudomonas aeruginosa. Using a streptozotocin–nicotinamide-induced diabetic excision wound model in Wistar rats, the probiotic gels demonstrated significantly enhanced wound contraction, accelerated closure, and histological evidence of collagen deposition and re-epithelialization compared to diabetic controls. By Day 21, probiotic-treated groups exhibited healing efficacy comparable to the standard treatment (Placentrex® gel), with formulations containing Lactobacillus sporogenes and...
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Posted by admin on Aug 31, 2025 in |
In the last few decades, carbon nanotubes (CNTs) have been the focus of significant research in the field of medicine owing to their unique characteristics and wide range of potential applications. Globally, there has been an urgent need to design and develop safe, effective, controllable, and targeted drug delivery systems, leading to the creation of a new class of therapeutic nanotubes. Research in nanotechnology and nanoscience is advancing to develop multifunctional CNTs with the desired features for future applications. Current perspectives on the applications of engineered carbon nanotubes in nanomedicine and bioengineering are focused on designing safe, effective, controllable, and targeted strategies. CNT-based drug delivery systems aim to deliver therapeutics to specific tissues, reduce adverse drug effects, enhance bioavailability, and repair damaged tissues. Additionally, they are utilized in detection, diagnostic, and monitoring devices. This review covers the recent developments in carbon nanotubes and their potential applicability with brief synthesis, functionalization, and the latest advancements in the medicinal chemistry of carbon...
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