Posted by admin on Jan 31, 2025 in |
GSTC is a polyherbal formulation comprising Commiphora mukul, Salacia reticulata, Terminalia arjuna, and Curcuma longa, developed to address atherosclerosis through multi-targeted mechanisms. Its phytochemical constituents include guggulsterones, mangiferin, arjunolic acid, and curcuminoids, each offering diverse pharmacological actions. Guggulsterones from C. mukul are recognized for their hypolipidemic and anti-inflammatory effects, while mangiferin and salacinol from S. reticulata provide antidiabetic, anti-obesity, and cholesterol-lowering benefits. T. arjuna contributes arjunolic acid and phytosterols, known for cardioprotective, antioxidant, and anti-inflammatory properties. Curcuminoids and ar-turmerone from C. longa exhibit potent antioxidant, anti-inflammatory, and hypolipidemic actions. Pharmacological studies demonstrate GSTC’s efficacy in reducing cholesterol, triglycerides, LDL, and VLDL levels while elevating HDL in high-fat diet models. Its mechanisms include inhibition of lipid peroxidation, regulation of HMG-CoA reductase, and modulation of inflammatory pathways such as NF-κB and COX-2. The formulation also prevents fatty liver accumulation and enhances lipid metabolism, GSTC exhibits significant antioxidant activity and platelet peroxidation inhibition. GSTC’s unique composition and pharmacological profile suggest its potential as a safe and effective therapeutic agent for managing atherosclerosis...
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Posted by admin on Jan 31, 2025 in |
Adhatoda vasica (L.) Nees is a well-known medicinal plant in both Ayurvedic and Unani traditions, widely used for treating various health issues, especially respiratory tract disorders. Over the past two decades, numerous scientific studies have highlighted the oxytocic and abortifacient properties of vasicine, an alkaloid derived from the plant. This paper provides an overview of the most recent research on its phytochemical and pharmacological properties. The review emphasizes the diverse range of phytochemical compounds extracted from the Adhatoda vasica plant and it possesses various activities like anti allergic, anti-tubercular, immunomodulatory, anti-asthmatic, bronchodilator, hepatoprotective, antiviral, anti-inflammatory, anti-fungal, anthelmintic, thrombolytic activities. Various phytochemicals like alkaloids, flavonoids, tannins, etc. were obtained from Adhatoda vasica (A. vasica). The active constituent of the plant is vasicine, l-vasicinone, deoxyvasicine, maiontone, vasicinolone and vasicinol etc. This review consists of updated information on the phyto-constituents isolated from A. vasica and their potential role in the treatment of various ailments traditionally and...
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Posted by admin on Dec 31, 2024 in |
Context: Obsessive-Compulsive disorder (OCD) is one of the most common neurological illness worldwide. Marble burying behavior in murine models is a unique and precise model for the assessment of anti-OCD like action of the tested drug. Lagenaria siceraria (Molina) Standley (LS), popularly known as “bottle gourd”, is a potent indigenous vegetable plant with high therapeutic value. Objective: The aim of this study was to evaluate the anti-OCD (anti-compulsive) effects of the methanolic extract of LS fruits (MLSF) and the phytosterol rich Chloroform fraction of methanolic extract of LS fruits (CFMLS) using the marble-burying test in mice. Materials and Methods: The screening of anti-OCD action was carried out on Swiss Albino mice. Moreover LC-MS/MS analysis was carried out for the isolation and identification of the bioactive phytoconstituents responsible for the anti-OCD like effect of CFMLS. Results and Conclusions: MLSF and CFMLS, at doses of 100, 200, and 400 mg/kg, p.o., decreased the total number of buried marbles in dose dependent manner. At dose of 400 mg/ kg, CFMLS exhibited the...
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Posted by admin on Dec 31, 2024 in |
This study explores the phytochemical composition and antimicrobial potential of Euphorbia hirta, a medicinal plant known for its therapeutic properties. Phytochemical screening of its aerial parts revealed the presence of bioactive compounds such as alkaloids, flavonoids, saponins, terpenoids, steroids, and sterols. Methanol extracts were evaluated for antimicrobial activity using the agar cup-plate diffusion method, demonstrating significant inhibitory effects against Escherichia coli. These findings highlight the plant’s natural antimicrobial properties, suggesting its potential as a valuable resource for addressing bacterial infections. Our findings suggest that Euphorbia hirta holds promise as a natural antimicrobial agent and Isolated Flavonoid from E. hirta Extracts shows maximum antimicrobial activity as compared with the whole extract of Euphorbia hirta. The study underscores the importance of Euphorbia hirta in the development of herbal-based therapeutics. Future research will focus on isolating and characterizing the active compounds responsible for its antimicrobial effects. Understanding the mechanisms of action of these compounds could lead to the creation of novel, plant-derived antibacterial agents, offering an alternative to conventional antibiotics in combating...
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Posted by admin on Dec 31, 2024 in |
Herbal insecticidal formulations using two indigenous plants were developed keeping in view disadvantages of the use of synthetic products and to embolden eco-friendly approach. Plants selected were screened for insecticidal and antifeedant activities. Oil in water emulsion-based creams and wettable powder were formulated. Creams were evaluated for different parameters like appearance, pH, spreadability, texture analysis, extrudability, homogeneity, skin irritation, short term stability study and estimation of phytoconstituents while powder granules for appearance, pH, wettability, persistent foaming, suspensibility, spontaneity of dispersion, particle size analysis and flow property. The formulations were found to be stable during stability study according to ICH guidelines. Results indicate that prepared herbal formulations can effectively be used as safe and user convenient...
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