Posted by admin on Feb 28, 2025 in |
An ayurvedic herb utilised since ancient times, Berberis aristata is an Indian medicinal plant that is a member of the Berberidaceae family. Other names for it are Daruharidra, Daruhaldi, Indian berberi, Darvi, and Chitra. Antipyretic, antibacterial, antimicrobial, anti-hepatotoxic, anti-hyperglycemic, anti-cancer, antioxidant, and antilipidemic properties are all beneficial properties of the plant. Additionally, gynaecological disorders, HIV-AIDS, osteoporosis, diabetes, eye and ear infections, wound healing, jaundice, skin illnesses, malarial fever, and diarrhoea can all be treated using B. aristata extracts and formulations. In order to provide insights into the development of possibly novel bioactives from plant scaffolds, this review attempts to emphasise the pharmacognostic and pharmacological uses of B. aristata. The geographic origins and taxonomy of Berberis aristata will also be highlighted in this review. The plant’s fruit is high in vitamin C and edible. This plant produces a very valuable ayurvedic concoction called Rashut, which is used as a laxative, tonic, and blood purifier to treat human ailments such ulcers and ocular diseases. According to phytochemical analyses, the plant B....
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Posted by admin on Feb 28, 2025 in |
Cleome gynandra (Capparaceae) is also known as spider plant. Cleome gynandra is an abundantly available species and grows as a weed in common barren land and in crop fields throughout India. In all over the world in different countries it is used to treat many diseases in their traditional system, and it is also used in various traditional culinary systems for its remarkable nutritional and antioxidant properties. In India alone it is used by the traditional healers for many diseases e.g. epilepsy, irritable bowel syndrome and in protozoal and worm infections. C. gynandra is typically well-known herb in southern Africa reaching out from the Limpopo, the North-West, Gauteng, the Northern Cape, and Namibia. The majority of these plants pharmacologically active phytochemicals are secondary metabolites produced during cellular metabolism. Cleome gynandra a valuable plant in traditional medicines and potential source for developing a therapeutic agent. In this review article through various established facts regarding the medicinal applications of Cleome gynandra has been cited regarding the Immunomodulator, Antioxidant, Anticarcinogenic, Analgesic properties...
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Posted by admin on Feb 28, 2025 in |
Kigelia pinnata Linn (Balam Kheera) Belongs to the family Bignoniace and commonly called as “Sausage tree” because of its hugs fruits. To study pharmacognosy and phytochemistry of kigelia pinnata and also studying Ayurveda, Siddha, Unani system of medicine. Kigelia Africana (lam) Benth. It is one of those tree species that have been heavily exploited for their medicinal, religious and cultural values. These species can reach 20 meters in height, sausage like in appearance with long cord-like talks. The species is native in Africa. Preliminary phytochemical screening performed on chloroform, petroleum ether, methanol, ethanol showed the presence of alkaloids, glycosides, flavonoids, steroids and tannins. The chemical constituent present in Kigelia pinnata is Naphthoquinone lapachol, pinnatal, isopinnatal, steroid is naphthoquinone, saponin, tannins, flavonoids. The collection of Kigelia pinnata leaves, fruits, stem, flowers etc. To study pharmacognostic characteristics of Kigelia pinnata leaves. The performance of the phytochemical screening of Kigelia pinnata leaves based on their physiochemical studies. To isolate pure phytoconstituent from extract by thin layer chromatography and elucidate structure of compound...
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Posted by admin on Feb 28, 2025 in |
Natural plant extracts have gained interest in cancer research due to their potential therapeutic properties. This study investigates the in-vitro cytotoxic effects and phytochemical composition of Mammea africana stem bark and Calophyllum inophyllum leaves methanol extracts against H460 lung cancer cells using the MTT assay, with 5-Fluorouracil (5FU) as a standard control. Phytochemical screening revealed that M. africana had high terpenoid content and moderate levels of flavonoids, tannins, and phenolics, while C. inophyllum had higher flavonoid and phenolic content, moderate saponins and terpenoids, and lower tannins and alkaloids. The extraction yields were 12.5% w/w for M. africana and 9.8% w/w for C. inophyllum. Cytotoxicity analysis demonstrated that M. africana exhibited strong cytotoxic effects, with an IC₅₀ value of 2.60 µg/mL, comparable to 5-Fluorouracil (IC₅₀ = 2.71 µg/mL), while C. inophyllum showed moderate cytotoxic activity (IC₅₀ = 30.00 µg/mL). The cytotoxic effects were dose-dependent, with M. africana achieving 97.47% cytotoxicity at 100 µg/mL, whereas C. inophyllum reached 85.4% at the same concentration. The findings suggest that the potent cytotoxic effects of Mammea africana could be attributed to its high terpenoid and tannin content, whereas the moderate activity of C. inophyllum may be linked...
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Posted by admin on Feb 28, 2025 in |
Cancer is a dangerous global disease and causes a heavy economic burden in low-income countries. Traditional medicinal plants play an important role in the research and development of cancer treatment drugs. Twenty-four traditional Vietnamese herbs were evaluated for their cytotoxic activities against nine cancer cell lines including HepG2, A549, MCF7, HT-29, HeLa, RD, LNCaP, HL-60 and NTERA-2. Cytotoxic activity was assessed following Monks’ protocol (1991) by measuring total cellular protein content using sulforhodamine B (SRB) staining. The 70% ethanol extract of eight medicinal herbs including Phyllanthus urinaria L. (TD.MD1), Solanum trilobatum L. (TD.MD2), Angelica sinensis (Oliv.) Diels (TD.MD3), Xanthium strumarium L. (TD.MD11), Scutellaria baicalensis Georgi (TD.MD15), Platycodon grandiflorus (Jacq.) A.D.C. (TD.MD17), Lycopodium clavatum L. (TD.MD20) and Ophiopogon japonicus (Thunb.) Ker Gawl. (TD.MD21) showed cytotoxic activity against HepG2, A549, MCF7, HT-29, HeLa, RD, LNCaP, HL-60 cell lines with IC50 values ranging from 18.60 to 93.84 µg/mL. The hexane, ethyl acetate, n-butanol, water extract residues of the 70% ethanol extracts demonstrated cytotoxic activities against NTERA-2 cell line with IC50 values of...
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