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ISSN (Online): 2348-3962,
ISSN (Print): 2394-5583

International Journal Of Pharmacognosy

An International Journal published monthly
ICV (2015): 69.75, Cosmos Impact Factor (2015): 4.693
DOI: 10.13040/IJPSR.0975-8232.IJP

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Posted by on Aug 5, 2008 in Blog | 0 comments

SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES

SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES

2-Amino-1-aryl-1,4,5,6,7,8-hexahydro-4-phenylquinoline-3-carbonitrile derivatives were synthesized by the reaction of cyclohexanone (1) with 2-benzylidinemalononitrile (2) and the appropriate of aniline derivatives. The reactivity of some of these newly synthesized derivatives toward carbon disulfide and further toward hydrazonoyl halides were also studied. In addition, the antimicrobial activity of the newly synthesized derivatives was reported.