RHOIFOLIN: A REVIEW OF SOURCES AND BIOLOGICAL ACTIVITIESAbstract
Flavonoids are common plant constituents used extensively in phytomedicine to treat a wide range of diseases. Many pharmacological pieces of evidence suggest that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. Therefore, this article focuses on the chemistry, distribution and pharmacological properties of rhoifolin as one of the common and important flavonoids in the plant kingdom. This flavonoid has also been found in several dietary sources such as bitter orange, bergamot, grapefruit, lemon, lupinus, lablab beans, tomatoes, artichoke, bananas, and grapes. Preclinical studies have shown that rhoifolin possesses a variety of significant biological activities including antioxidant, anti-inflammatory, antimicrobial, hepatoprotective and anticancer effects. The literature search was conducted using electronic databases (e.g., Medline, Pubmed, Academic Journals and Springer Link), general web searches were also undertaken using Google applying some related search, journals and scientific theses. The bibliographies of papers relating to the review subject were also searched for further relevant references.
J. Refaat *, S. Y. Desoukey, M. A. Ramadan and M. S. Kamel
Pharmacognosy Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
29 December 2014
25 January 2015
23 February 2015
01 March 2015