REVIEW ON ANTI-MICROBIAL PROPERTIES OF MEDICINAL PLANTS IN ETHIOPIAAbstract
Infectious diseases are one of the major problems in the world. After the discovery of penicillin, many classes of the antimicrobial agent were introduced and most infectious diseases were brought under control. However, the increased use of these antimicrobial agents in clinical practice was soon followed by the emergence of antibiotic resistance. Because of multiple drug resistance and adverse effects of these antimicrobial agents on the host, there is the need to discover and develop natural antimicrobials that are safe and with better therapeutic effects. Medicinal plants have been used as an alternative source of medicine to treat infectious diseases due to their rich antimicrobial activity. These Plants contain bioactive compounds such as quinines, phytoalexins, phenols, alkaloids, flavonoids, terpenoids, steroids, tannins, glucosinolates and pathogenesis-related proteins, which exert antimicrobial activity by different mechanisms, such as destruction of the cell membrane, inhibition of protein synthesis and enzymes impregnated on the cell membrane. There are various extracts of medicinal plants with minimum inhibitory concentration against pathogenic microorganisms that are safe and effective as therapeutic agents. In this review, data on 91 medicinal plants from Ethiopia distributed in 49 families against 27 species of bacteria, 11 species of fungi were assessed, to provide information, and opportunity for further analysis of medicinal plant extracts for the development of effective antimicrobial agents.
T. M. Belete
Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
28 August 2019
23 September 2019
28 September 2019
30 September 2019