PHYTOCHEMICAL SCREENING AND HEPATOPROTECTIVE EFFICACY OF LEAVES EXTRACTS OF ANNONA SQUAMOSA AGAINST PARACETAMOL INDUCED LIVER TOXICITY IN RATSAbstract
Phytochemicals are the best remedies to all kind of diseases and disorders throughout the world. There are a lot of plants, and its sources are playing a role as a heart, liver and kidney savers. In our present investigation, the famous fruit tree Annona squamosa (Annonaceae) leaves extract used for the hepatoprotective activity. The phytochemicals present in the aqueous leaves extracts were analyzed using preliminary biochemical analysis, and functional groups are characterized using Fourier Transform Infrared Spectrophotometer (FT-IR). The animals were divided into six groups, in that apart from the first group (normal control), five groups are induced with paracetamol (acetaminophen) with standard drug and two plant drug extracted by aqueous one is induced control. The increasing of enzymes and bilirubin, triglycerides and cholesterol and decreasing protein shows the liver damage. These levels are changed into normal range indicates efficiency of our plant drug. The histopathalogical results are also confirmed our hepatoprotective capability is good.
S. Rajeshkumar*, B. Tamilarasan and V. Sivakumar
PG and Research Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai, Vellore, Tamil Nadu, India.
14 January 2015
15 March 2015
29 March 2015
01 April 2015