PHYTOCHEMICAL PROFILE, ACUTE TOXICITY, AND ANTINOCICEPTIVE POTENTIAL OF METHANOLIC EXTRACT OF CITRUS AURANTIFOLIA PEELS
AbstractPeople worldwide have long sought effective ways to alleviate pain, a major symptom of many clinical conditions. To achieve better pain control, there is a continuous need to discover new and effective therapeutic agents. Lime peels (Citrus aurantifolia) have been traditionally used to manage various ailments, including pain and infections, and have also been reported to protect several vital organs. Preliminary phytochemical screening and oral acute toxicity studies were conducted on Citrus aurantifolia peels extract (CAPE). No mortality was recorded during the acute toxicity study; therefore, the LD₅₀ of CAPE was estimated to be greater than 2000 mg/kg. In the acetic acid–induced writhing test, CAPE produced significant (p < 0.001) and non–dose-dependent inhibition of pain, with percentage reductions of 56.9%, 66.5%, and 64.9% at doses of 100, 200, and 400 mg/kg, respectively. In the formalin-induced pain model, CAPE at 200 and 400 mg/kg significantly (p < 0.001) reduced paw-licking time in both the first and second phases. In addition, CAPE significantly increased latency time (area under the curve) and maximal effect compared with the control group in the hot plate test. These findings suggest that Citrus aurantifolia peels extract may serve as a promising phytotherapeutic agent for the management of nociceptive pain.
Article Information
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80-87
582 KB
16
English
IJP
Elijah Oladapo Oyinloye *, Abdullahi Akanji Murtala, Farouk Adedeji Oladoja, Rasidat Olufunke Tijani, Mu’d-Uwaiz Oluwatomisin Abdullah, Esther Oluwabunmi Adeniyi and Emmanuel Pelumi Sodamola
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria.
oyinloye.oladapo@oouagoiwoye.edu.ng
27 January 2026
23 February 2026
26 February 2026
10.13040/IJPSR.0975-8232.IJP.13(2).80-87
28 February 2026
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