PHYTOCHEMICAL ANALYSIS AND ACUTE TOXICITY STUDY OF METHANOLIC LEAF EXTRACT OF COLOCASIA GIGANTEA IN ADULT MALE WISTAR RATS
AbstractBackground: Colocasia gigantea is a large, stemless, tuberous, frost-tender perennial of the arum family, which typically grows tall and wide. It is found abundantly in tropical countries, and in Southeast Asia. Methodology and Results: Phytochemical analysis using gas chromatography and acute toxicity testing was done on methanolic leaf extract of Colocasia gigantea. The adult male wistar rats used for acute toxicity testing were 13 in number. The results showed that at 5000mg/kg, of administration of methanolic leaf extract Colocasia gigantean, no death occurred among the wistar rats used for the study. Phytochemical analysis results on methanolic leaf extract of Colocasia gigantea showed the presence of flavonoids (flavon – 3-ol and flavone), alkaloids, tannins, nobiletin, artemetin. Conclusion: Methanolic leaf extract of Colocasia gigantea contains substances of significant medicinal values and acute administration of methanolic leaf extract is relatively non-toxic.
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