EVALUATION OF ANALGESIC ACTIVITY OF THE DIFFERENT FRACTIONS OF TYPHA ELEPHANTINA ROXB.Abstract
This study was aimed to investigate the analgesic activity of the different fractions of Typha elephantina Roxb. Analgesic activity was evaluated for peripheral pharmacological actions using the acetic acid-induced writhing test in Swiss albino mice. The result of preliminary phytochemical screening reveals that different fractions of Typha elephantina Roxb. contains alkaloids, flavonoids, tannins, and carbohydrates. All fractions at the doses of 200 and 400 mg/kg b.w. they have produced significant (P<0.05) analgesic action in a dose-dependent manner in the tested model. In acetic acid-induced writhing test, petroleum ether, carbon tetrachloride and ethyl acetate fractions of roots (400 mg/kg) inhibited maximum 62.59%, 66.14%, and 69.29% writhing respectively, whereas the writhing inhibition of the standard drug Diclofenac-Na (25 mg/kg) was 71.65%.
M. M. Rahman, J. K. Chakrabarty, M. A. Muhit and P. R. Dash *
Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.
21 April 2014
21 May 2014
30 May 2014
01 June 2014