ESSENTIAL OIL OF CAMPOMANESIA AUREA: CHEMICAL COMPOSITION AND ANTI-NEOPLASTIC POTENTIAL IN-VITROAbstract
Cervical cancer is a highly prevalent global disease among females and currently available treatments are nevertheless restricted and have substantial adverse effects. Plants may be a rich source of molecules with therapeutic potentials, such as Campomanesia aureas O. Berg, Myrtaceae, a native species from the South of Brazil with few data regarding its biological effects. In this study, we investigated the chemical composition and antineoplastic potential in-vitro of the essential oil (EO) of C. aureas leaves in human cervical cancer cells (SiHa), as well as its effect in the viability of non-tumoral cells (HaCat). CG-MS analysis reveals that the EO is rich in oxygenated sesquiterpenes and monoterpenes and MTT colorimetric assay shows that it significantly inhibits the viability of the SiHa cell line at different concentrations. Besides, the EO reduced the colony-forming capacity of the tumor cell line, and the ratio between the IC50 values of cell lines demonstrated a promising selectivity index for C. aurea EO. Therefore, the EO could be a potential source of new anticancer molecules.
H. O. Garcia *, L. A. Pacheco, J. G. Nuñez, G. C. Pinto, V. G. La Porta, G. L. Padilha, E. M. Ethur, L. Hoehne and A. N. Bruno
Research Laboratory for Antineoplastic Compounds, Federal Institute of Education, Science and Technology of Rio Grande do Sul - Campus Porto Alegre, Rua Coronel Vicente, Centro Histórico, Porto Alegre, Brazil.
27 August 2020
23 September 2020
22 November 2020
31 December 2020