ANTIDIARRHEAL AND ANTIBACTERIAL ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF SALVIA SCHIMPERI BENTH FROM ETHIOPIAAbstract
In Ethiopian folk medicine, aqueous decoction of the leaves of Salvia schimperi is used for treatments of various ailments including diarrhea, however, to date, there appear to have been no reports on the phytochemistry, the antidiarrhoeal and the antimicrobial activity of the plant. In this study, the hydroalcoholic extract of the leaves of S. schimperi was evaluated for its antidiarrheal and antibacterial activities against castor oil induced diarrhea in mice and six clinically isolated enteric bacterial pathogens using standard agar diffusion methods, respectively. The minimum inhibitory concentrations (MIC) of the extracts were also determined using the microdilution method. The extract exerted significant and dose-related antidiarrhoeal activity when compared to the control and the standard drug, loperamide. The extract displayed highest antidiarrhoeal activity at a dose of 400 mg/kg which is comparable with that of the standard drug loperamide. The extract also showed moderate antibacterial effects against most of the test microorganisms except S. typhimurium. Phytochemical analysis of the extract revealed the presence of polyphenolic compounds such as flavonoids and tannins among others. The present study supports the folkloric use of the plant for the treatment of diarrhoeal diseases.
S. Umer *, G. Andualem, F. Getnet, H. Alemayehu, A. Tekewe and N. Kebede
School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
18 January 2015
25 May 2015
28 June 2015
30 June 2015