ANTI- NOCICEPTIVE ACTIVITY OF SPIRULINA PLATENSIS IN MICEAbstract
Spirulina platensis is a blue-green alga that widely used as a food supplement over worldwide. Two models were used to study the effects of Spirulina platensis on nociception which was induced by acetic acid (Writhing test), formalin (Paw licking test). Spirulina platensis was administered in the dose range of 200 and 400 mg/kg orally 1 h before pain induction. Spirulina platensis contains β-carotene and biliproteins (phycocyanin and biliphycocyanin). Oral administration of Spirulina platensis revealed dose-dependent antinociceptive effect in all the models for antinociception, and it blocked both the neurogenic and inflammatory pain, and the nociceptive activity was comparable with the reference drug. The results indicate that 400 mg/kg dose of Spirulina platensis showed significant antinociceptive activity. The activity can be related with the significant biliprotein such as phycocyanin and biliphycocyanin that have potent antioxidant activity.
S. Neekhra, S. Jain, S. A. Jain, N. K. Garg, A. Jain , V. Jain, P. Jain and A. Jain*
Bhagyoday Tirth Pharmacy College, Khurai Road, Sagar, Madhya Pradesh, India.
27 June 2014
21 July 2014
28 July 2014
01 August 2014