DESIGN, SYNTHESIS, AND PHARMACOLOGICAL ASSESSMENT OF NEW BENZOXAZOLE-BASED COMPOUNDS
AbstractA series of novel benzoxazole derivatives (4a–4i) were designed, synthesized, and evaluated for their in-vitro antifungal activity against seven phytopathogenic fungi, including G. saubinetii, T. cucumeris, S. sclerotiorum, V. dahliae, F. oxysporum, P. capsici and F. proliferatum, using the mycelial growth inhibition method. All compounds were initially screened at 100 mg/L, and active compounds were further assessed for EC₅₀ values. The synthesized derivatives showed moderate to excellent antifungal activity, with compound 4g exhibiting the most potent and broad-spectrum inhibition, outperforming standard fungicides mandipropamid and hymexazol. Compounds 4f and 4h also displayed strong activity against selected fungal strains. Structure–activity relationship analysis indicated that halogen substitution significantly influenced antifungal efficacy. The results suggest that benzoxazole-based scaffolds, particularly compound 4g, represent promising leads for the development of new antifungal agents for agricultural applications.
Article Information
10
464-469
552 KB
10
English
IJP
Amreesh Singh *, Yogendra Singh and Saurabh Jain
Shri Ramnath Singh Mahavidyalaya (Pharmacy), Gormi, Bhind, Madhya Pradesh, India.
mspharma8081@gmail.com
16 April 2026
07 May 2026
12 May 2026
10.13040/IJPSR.0975-8232.IJP.13(5).464-69
15 May 2026
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